STX1B
Gene Ontology Biological Process
- intracellular protein transport [IBA]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of neurotransmitter secretion [ISS]
- regulation of gene expression [ISS]
- regulation of synaptic vesicle priming [ISS]
- synaptic vesicle docking [ISS]
- synaptic vesicle fusion to presynaptic membrane [IBA]
- vesicle docking [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
VAMP2
Gene Ontology Biological Process
- Golgi to plasma membrane protein transport [ISS]
- calcium ion-dependent exocytosis [ISS]
- cellular protein metabolic process [TAS]
- cellular response to insulin stimulus [ISS]
- energy reserve metabolic process [TAS]
- eosinophil degranulation [IMP]
- exocytosis [IBA, TAS]
- glutamate secretion [TAS]
- long-term synaptic potentiation [ISS]
- membrane fusion [ISS]
- membrane organization [TAS]
- mucus secretion [IMP]
- natural killer cell degranulation [IMP]
- neurotransmitter secretion [TAS]
- neutrophil degranulation [IMP]
- positive regulation of intracellular protein transport [ISS]
- post-Golgi vesicle-mediated transport [TAS]
- protein complex assembly [ISS]
- protein transport [ISS]
- regulation of exocytosis [ISS]
- regulation of histamine secretion by mast cell [IMP]
- regulation of insulin secretion [TAS]
- regulation of vesicle-mediated transport [ISS]
- response to glucose [ISS]
- small molecule metabolic process [TAS]
- synaptic transmission [TAS]
- synaptic vesicle exocytosis [ISS, TAS]
- vesicle fusion [IBA]
- vesicle-mediated transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SNARE complex [IDA, TAS]
- clathrin-coated vesicle [IDA]
- clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [TAS]
- clathrin-sculpted glutamate transport vesicle membrane [TAS]
- clathrin-sculpted monoamine transport vesicle membrane [TAS]
- cytoplasmic vesicle [ISS]
- endocytic vesicle membrane [TAS]
- extracellular vesicular exosome [IDA]
- integral component of plasma membrane [TAS]
- intracellular membrane-bounded organelle [ISS]
- membrane [IDA]
- neuron projection [ISS]
- neuron projection terminus [ISS]
- perinuclear region of cytoplasm [ISS]
- plasma membrane [ISS, TAS]
- secretory granule [ISS]
- secretory granule membrane [IDA, TAS]
- synapse [ISS]
- synaptic vesicle [IBA, ISS, TAS]
- synaptic vesicle membrane [ISS]
- synaptobrevin 2-SNAP-25-syntaxin-1a complex [ISS]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [ISS]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex [ISS]
- trans-Golgi network [ISS]
- zymogen granule membrane [ISS]
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay.
Syntaxin 1 and synaptobrevin/VAMP play an essential role in synaptic vesicle exocytosis. Two isoforms for each of these proteins, syntaxins 1A and 1B and synaptobrevin/VAMPs 1 and 2, have been found in nerve endings. Morphological and biochemical studies have revealed a characteristic colocalization and selective interactions patterns of syntaxin 1 and synaptobrevin/VAMP isoforms in nervous and endocrine systems. Moreover, studies ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| STX1B VAMP2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | 2704362 |
Curated By
- BioGRID