LHX2
Gene Ontology Biological Process
CITED2
Gene Ontology Biological Process
- adrenal cortex formation [ISS]
- cell proliferation [IDA]
- determination of left/right symmetry [ISS]
- embryonic heart tube left/right pattern formation [ISS]
- heart development [IMP, ISS]
- left/right axis specification [ISS]
- liver development [ISS]
- negative regulation of apoptotic process [ISS]
- negative regulation of cell migration [IMP]
- negative regulation of gene expression [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [ISS]
- outflow tract morphogenesis [ISS]
- positive regulation of cell cycle [ISS]
- positive regulation of cell-cell adhesion [ISS]
- positive regulation of gene expression [IDA]
- positive regulation of male gonad development [ISS]
- positive regulation of peroxisome proliferator activated receptor signaling pathway [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- positive regulation of transforming growth factor beta receptor signaling pathway [ISS]
- regulation of nucleic acid-templated transcription [IDA]
- regulation of organ formation [ISS]
- response to estrogen [IDA]
- response to fluid shear stress [IMP]
- response to hypoxia [IDA, IMP]
- sex determination [ISS]
- spleen development [ISS]
- ventricular septum morphogenesis [ISS]
Gene Ontology Molecular Function- LBD domain binding [IPI]
- RNA polymerase II transcription corepressor activity [IDA]
- chromatin binding [ISS]
- histone acetyltransferase binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [ISS]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA, IMP]
- LBD domain binding [IPI]
- RNA polymerase II transcription corepressor activity [IDA]
- chromatin binding [ISS]
- histone acetyltransferase binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [ISS]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA, IMP]
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression.
Tissue-specific expression of the alpha-subunit gene of glycoprotein hormones involves an enhancer element designated the pituitary glycoprotein basal element, which interacts with the LIM homeodomain transcription factor, Lhx2. In the present studies we have explored the function of the LIM domain of Lhx2 in stimulating alpha-subunit transcription. When fused to the GAL4 DNA-binding domain, the LIM domain of Lhx2 was ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LHX2 CITED2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| LHX2 CITED2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID