GPLD1
Gene Ontology Biological Process
- GPI anchor release [IDA, IMP]
- cell migration involved in sprouting angiogenesis [IMP]
- cellular response to calcium ion [IDA]
- cellular response to cholesterol [IMP]
- cellular response to drug [IDA]
- cellular response to insulin stimulus [IDA]
- cellular response to pH [IDA]
- cellular response to triglyceride [IMP]
- chondrocyte differentiation [ISS]
- complement receptor mediated signaling pathway [IDA]
- hematopoietic stem cell migration [TAS]
- hematopoietic stem cell migration to bone marrow [TAS]
- insulin receptor signaling pathway [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of triglyceride catabolic process [ISS]
- ossification [ISS]
- phosphatidylcholine metabolic process [ISS, TAS]
- positive regulation of alkaline phosphatase activity [ISS]
- positive regulation of apoptotic process [IDA]
- positive regulation of cytolysis [IDA]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of glucose metabolic process [ISS]
- positive regulation of high-density lipoprotein particle clearance [ISS]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [ISS]
- positive regulation of membrane protein ectodomain proteolysis [IDA]
- positive regulation of secretion [ISS]
- positive regulation of triglyceride biosynthetic process [ISS]
- regulation of cellular response to insulin stimulus [IDA]
- response to glucose [IDA]
- transepithelial transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
APOA1
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [IDA]
- G-protein coupled receptor signaling pathway [IDA]
- blood coagulation [TAS]
- cellular lipid metabolic process [TAS]
- cholesterol efflux [IDA]
- cholesterol homeostasis [IDA, IMP]
- cholesterol import [IMP]
- cholesterol metabolic process [IMP]
- cholesterol transport [IDA]
- high-density lipoprotein particle assembly [IDA]
- high-density lipoprotein particle clearance [IC]
- high-density lipoprotein particle remodeling [IC]
- integrin-mediated signaling pathway [IDA]
- lipoprotein metabolic process [TAS]
- negative chemotaxis [IDA]
- negative regulation of cell adhesion molecule production [IDA]
- negative regulation of cytokine secretion involved in immune response [IDA]
- negative regulation of heterotypic cell-cell adhesion [IDA]
- negative regulation of inflammatory response [IDA]
- negative regulation of interleukin-1 beta secretion [IDA]
- negative regulation of response to cytokine stimulus [IDA]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IDA]
- negative regulation of very-low-density lipoprotein particle remodeling [IDA]
- peptidyl-methionine modification [IDA]
- phosphatidylcholine biosynthetic process [IDA]
- phospholipid efflux [IDA]
- phospholipid homeostasis [IDA]
- phototransduction, visible light [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of Rho protein signal transduction [IDA]
- positive regulation of cholesterol esterification [IDA]
- positive regulation of hydrolase activity [IDA]
- positive regulation of stress fiber assembly [IDA]
- positive regulation of substrate adhesion-dependent cell spreading [IDA]
- protein oxidation [IDA]
- protein stabilization [IDA]
- regulation of Cdc42 protein signal transduction [IDA]
- retinoid metabolic process [TAS]
- reverse cholesterol transport [IMP]
- small molecule metabolic process [TAS]
- transforming growth factor beta receptor signaling pathway [IDA]
- transmembrane transport [TAS]
- triglyceride homeostasis [IDA]
Gene Ontology Molecular Function- apolipoprotein A-I receptor binding [IPI]
- apolipoprotein receptor binding [IPI]
- beta-amyloid binding [IDA]
- chemorepellent activity [IDA]
- cholesterol binding [IDA]
- cholesterol transporter activity [IDA, IMP]
- enzyme binding [IPI]
- high-density lipoprotein particle receptor binding [IPI]
- identical protein binding [IPI]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IDA]
- phospholipid binding [IDA]
- protein binding [IPI]
- apolipoprotein A-I receptor binding [IPI]
- apolipoprotein receptor binding [IPI]
- beta-amyloid binding [IDA]
- chemorepellent activity [IDA]
- cholesterol binding [IDA]
- cholesterol transporter activity [IDA, IMP]
- enzyme binding [IPI]
- high-density lipoprotein particle receptor binding [IPI]
- identical protein binding [IPI]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IDA]
- phospholipid binding [IDA]
- protein binding [IPI]
Gene Ontology Cellular Component
- blood microparticle [IDA]
- cytoplasmic vesicle [IDA]
- cytosol [TAS]
- early endosome [TAS]
- endocytic vesicle [IDA]
- endocytic vesicle lumen [TAS]
- endoplasmic reticulum lumen [TAS]
- extracellular region [TAS]
- extracellular space [IDA, ISS]
- extracellular vesicular exosome [IDA]
- high-density lipoprotein particle [IDA]
- plasma membrane [TAS]
- secretory granule lumen [TAS]
- spherical high-density lipoprotein particle [IDA]
- very-low-density lipoprotein particle [IDA]
- vesicle [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex.
Glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) is abundant in serum and associates with high density lipoproteins (HDL). We have characterized the distribution of GPI-PLD among lipoproteins in human plasma. Apolipoprotein (apo)-specific lipoproteins containing apoB (Lp[B]), apoA-I and A-II (Lp[A-I, A-II]), or apoA-I only (Lp[A-I]) were isolated using dextran sulfate and immunoaffinity chromatography. In six human plasma samples with HDL cholesterol ranging from ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GPLD1 APOA1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID