GPLD1
Gene Ontology Biological Process
- GPI anchor release [IDA, IMP]
- cell migration involved in sprouting angiogenesis [IMP]
- cellular response to calcium ion [IDA]
- cellular response to cholesterol [IMP]
- cellular response to drug [IDA]
- cellular response to insulin stimulus [IDA]
- cellular response to pH [IDA]
- cellular response to triglyceride [IMP]
- chondrocyte differentiation [ISS]
- complement receptor mediated signaling pathway [IDA]
- hematopoietic stem cell migration [TAS]
- hematopoietic stem cell migration to bone marrow [TAS]
- insulin receptor signaling pathway [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of triglyceride catabolic process [ISS]
- ossification [ISS]
- phosphatidylcholine metabolic process [ISS, TAS]
- positive regulation of alkaline phosphatase activity [ISS]
- positive regulation of apoptotic process [IDA]
- positive regulation of cytolysis [IDA]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of glucose metabolic process [ISS]
- positive regulation of high-density lipoprotein particle clearance [ISS]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [ISS]
- positive regulation of membrane protein ectodomain proteolysis [IDA]
- positive regulation of secretion [ISS]
- positive regulation of triglyceride biosynthetic process [ISS]
- regulation of cellular response to insulin stimulus [IDA]
- response to glucose [IDA]
- transepithelial transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
APOA4
Gene Ontology Biological Process
- cholesterol efflux [IDA]
- cholesterol homeostasis [IDA]
- cholesterol metabolic process [IDA]
- chylomicron assembly [TAS]
- chylomicron remodeling [IC]
- high-density lipoprotein particle remodeling [IC]
- hydrogen peroxide catabolic process [IDA]
- innate immune response in mucosa [IDA]
- leukocyte cell-cell adhesion [IDA]
- lipid homeostasis [IDA]
- lipid transport [IDA]
- lipoprotein metabolic process [TAS]
- multicellular organismal lipid catabolic process [IDA]
- negative regulation of plasma lipoprotein particle oxidation [IDA]
- phosphatidylcholine metabolic process [IDA]
- phospholipid efflux [IDA]
- phototransduction, visible light [TAS]
- positive regulation of cholesterol esterification [IDA]
- positive regulation of fatty acid biosynthetic process [IDA]
- positive regulation of lipoprotein lipase activity [IDA]
- positive regulation of triglyceride catabolic process [IDA]
- protein-lipid complex assembly [IMP]
- regulation of cholesterol transport [IDA]
- removal of superoxide radicals [IDA]
- response to lipid hydroperoxide [IDA]
- retinoid metabolic process [TAS]
- reverse cholesterol transport [IDA]
- small molecule metabolic process [TAS]
- very-low-density lipoprotein particle remodeling [IDA]
Gene Ontology Molecular Function- antioxidant activity [IDA]
- cholesterol transporter activity [IDA]
- copper ion binding [IDA]
- lipid binding [IMP]
- lipid transporter activity [TAS]
- phosphatidylcholine binding [IDA]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- antioxidant activity [IDA]
- cholesterol transporter activity [IDA]
- copper ion binding [IDA]
- lipid binding [IMP]
- lipid transporter activity [TAS]
- phosphatidylcholine binding [IDA]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
Gene Ontology Cellular Component
- blood microparticle [IDA]
- cell surface [IDA]
- chylomicron [IDA]
- cytosol [TAS]
- early endosome [TAS]
- endoplasmic reticulum lumen [TAS]
- extracellular region [NAS, TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- high-density lipoprotein particle [IDA]
- very-low-density lipoprotein particle [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex.
Glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) is abundant in serum and associates with high density lipoproteins (HDL). We have characterized the distribution of GPI-PLD among lipoproteins in human plasma. Apolipoprotein (apo)-specific lipoproteins containing apoB (Lp[B]), apoA-I and A-II (Lp[A-I, A-II]), or apoA-I only (Lp[A-I]) were isolated using dextran sulfate and immunoaffinity chromatography. In six human plasma samples with HDL cholesterol ranging from ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GPLD1 APOA4 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID