BAIT
ERCC6
ARMD5, CKN2, COFS, COFS1, CSB, RAD26, UVSS1
excision repair cross-complementation group 6
GO Process (11)
GO Function (10)
GO Component (4)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- DNA repair [TAS]
- base-excision repair [IMP]
- nucleotide-excision repair [TAS]
- positive regulation of DNA-templated transcription, elongation [IDA]
- positive regulation of protein tyrosine kinase activity [IDA]
- regulation of DNA-templated transcription, elongation [IDA]
- response to UV [IDA]
- response to oxidative stress [IDA, IGI]
- transcription from RNA polymerase II promoter [NAS]
- transcription-coupled nucleotide-excision repair [IMP, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RPS15A
S15a, OK/SW-cl.82
ribosomal protein S15a
GO Process (16)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- SRP-dependent cotranslational protein targeting to membrane [TAS]
- cellular protein metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- positive regulation of cell cycle [IDA]
- positive regulation of cell proliferation [IDA]
- response to virus [IDA]
- translation [IC, NAS, TAS]
- translational elongation [TAS]
- translational initiation [TAS]
- translational termination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
- viral transcription [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Transcription-coupled nucleotide excision repair is coordinated by ubiquitin and SUMO in response to ultraviolet irradiation.
Cockayne Syndrome (CS) is a severe neurodegenerative and premature aging autosomal-recessive disease, caused by inherited defects in the CSA and CSB genes, leading to defects in transcription-coupled nucleotide excision repair (TC-NER) and consequently hypersensitivity to ultraviolet (UV) irradiation. TC-NER is initiated by lesion-stalled RNA polymerase II, which stabilizes the interaction with the SNF2/SWI2 ATPase CSB to facilitate recruitment of the ... [more]
Nucleic Acids Res. Dec. 10, 2019; 48(1);231-248 [Pubmed: 31722399]
Throughput
- High Throughput
Curated By
- BioGRID