CCR1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [TAS]
- calcium ion transport [IDA]
- cell adhesion [TAS]
- cell surface receptor signaling pathway [TAS]
- cell-cell signaling [IDA]
- cellular calcium ion homeostasis [IDA]
- chemokine-mediated signaling pathway [IDA]
- chemotaxis [NAS]
- cytokine-mediated signaling pathway [NAS]
- dendritic cell chemotaxis [TAS]
- exocytosis [IDA]
- immune response [IDA]
- metabolic process [IDA]
- negative regulation of bone mineralization [IMP]
- negative regulation of gene expression [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of calcium ion transport [IDA]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of monocyte chemotaxis [IDA]
- positive regulation of osteoclast differentiation [IMP]
- response to wounding [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PRNP
Gene Ontology Biological Process
- axon guidance [TAS]
- cellular copper ion homeostasis [NAS]
- metabolic process [TAS]
- negative regulation of T cell receptor signaling pathway [ISS]
- negative regulation of activated T cell proliferation [ISS]
- negative regulation of calcineurin-NFAT signaling cascade [ISS]
- negative regulation of interferon-gamma production [ISS]
- negative regulation of interleukin-17 production [ISS]
- negative regulation of interleukin-2 production [ISS]
- negative regulation of protein phosphorylation [ISS]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISS]
- response to oxidative stress [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
G-protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to their complex biochemical features. To obtain a global view of GPCR-mediated signaling and to identify novel components of their pathways, we used a modified membrane yeast two-hybrid (MYTH) ... [more]
Throughput
- Low Throughput
Additional Notes
- assayed using BRET (bioluminescent resonance energy transfer)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
CCR1 PRNP | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | 2827099 |
Curated By
- BioGRID