BAIT
MEGF10
EMARDD
multiple EGF-like-domains 10
GO Process (7)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
- homotypic cell-cell adhesion [IDA]
- muscle cell development [IMP]
- regulation of muscle cell differentiation [IMP]
- regulation of skeletal muscle tissue development [IMP]
- skeletal muscle satellite cell activation [ISS]
- skeletal muscle satellite cell differentiation [IMP]
- skeletal muscle satellite cell proliferation [ISS]
Homo sapiens
PREY
VIM
CTRCT30, HEL113, RP11-124N14.1
vimentin
GO Process (4)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
MEGF10 is a mammalian ortholog of CED-1 that interacts with clathrin assembly protein complex 2 medium chain and induces large vacuole formation.
The mechanisms underlying the engulfment of apoptotic corpses, which is involved in development, cellular homeostasis, and autoimmunity, remain largely unknown in mammals. MEGF10 is a mammalian ortholog of nematode CED-1, a transmembrane protein involved in engulfment of apoptotic corpses. MEGF10-expressing cells display an irregular, mosaic-like pattern of MEGF10, causing cells to tightly adhere to coated glass dishes. This restricted cell ... [more]
Exp. Cell Res. Oct. 15, 2007; 313(17);3729-42 [Pubmed: 17643423]
Throughput
- Low Throughput
Curated By
- BioGRID