BAIT

SLC22A1

HOCT1, OCT1, oct1_cds

solute carrier family 22 (organic cation transporter), member 1

GO Process (4)

GO Function (2)

GO Component (3)

Gene Ontology Biological Process

drug transmembrane transport [TAS]

organic cation transport [TAS]

small molecule metabolic process [TAS]

transmembrane transport [TAS]

Gene Ontology Molecular Function

organic cation transmembrane transporter activity [TAS]
protein binding [IPI]

Gene Ontology Cellular Component

integral component of plasma membrane [TAS]

plasma membrane [TAS]

CRISPR Database VEGA OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

VAPB

ALS8, VAMP-B, VAP-B, RP5-1018E9.1

VAMP (vesicle-associated membrane protein)-associated protein B and C

GO Process (16)

GO Function (7)

GO Component (5)

Gene Ontology Biological Process

COPII-coated vesicle budding [IMP]

ER to Golgi vesicle-mediated transport [IMP]

activation of signaling protein activity involved in unfolded protein response [IDA]

cellular calcium ion homeostasis [IMP]

endoplasmic reticulum organization [IMP]

endoplasmic reticulum unfolded protein response [IMP]

modulation by virus of host morphology or physiology [IDA]

negative regulation by host of viral genome replication [IDA]

negative regulation by host of viral release from host cell [IDA]

negative regulation by virus of viral protein levels in host cell [IDA]

positive regulation by host of viral genome replication [IDA]

positive regulation by host of viral release from host cell [IDA]

positive regulation of viral genome replication [IMP]

small molecule metabolic process [TAS]

sphingolipid biosynthetic process [TAS]

sphingolipid metabolic process [TAS]

Gene Ontology Molecular Function

FFAT motif binding [IMP]
beta-tubulin binding [IDA]
enzyme binding [IPI]
microtubule binding [IDA]
protein binding [IPI]
protein heterodimerization activity [IPI]
protein homodimerization activity [IPI]

Gene Ontology Cellular Component

Golgi apparatus [IDA]

Golgi membrane [IMP]

endoplasmic reticulum [IDA]

endoplasmic reticulum exit site [IDA]

endoplasmic reticulum membrane [IDA, TAS]

CRISPR Database VEGA HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PCA

A Protein-Fragment Complementation Assay (PCA) is a protein-protein interaction assay in which a bait protein is expressed as fusion to one of the either N- or C- terminal peptide fragments of a reporter protein and prey protein is expressed as fusion to the complementary N- or C- terminal fragment of the same reporter protein. Interaction of bait and prey proteins bring together complementary fragments, which can then fold into an active reporter, e.g. the split-ubiquitin assay.

Publication

Identification of the Tetraspanin CD9 as an Interaction Partner of Organic Cation Transporters 1 and 2.

Snieder B, Brast S, Grabner A, Buchholz S, Schroeter R, Spoden GA, Florin L, Salomon J, Albrecht T, Barz V, Sparreboom A, Ciarimboli G

Organic cation transporters (OCTs) are membrane proteins with relevant physiological (because they accept neurotransmitters as substrate) and pharmacological (because of their interaction with drugs) roles. The human OCTs hOCT1 (SLC22A1/hOCT1) and hOCT2 (SLC22A2/hOCT2) are highly expressed in hepatic (hOCT1) and in renal and neuronal tissue (hOCT2), suggesting a possible role in modulating neurotransmitter activity in the liver, kidney, and brain, ... [more]

SLAS Discov Dec. 01, 2018; 24(9);904-914 [Pubmed: 31318583]

Throughput

High Throughput

Curated By

BioGRID