SLC22A2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CCL2
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [TAS]
- JAK-STAT cascade [TAS]
- MAPK cascade [IMP]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- angiogenesis [TAS]
- astrocyte cell migration [IDA]
- cell adhesion [TAS]
- cell surface receptor signaling pathway [TAS]
- cellular homeostasis [TAS]
- cellular protein metabolic process [TAS]
- cellular response to fibroblast growth factor stimulus [IEP]
- cellular response to interferon-gamma [IEP, ISS]
- cellular response to interleukin-1 [IEP, ISS]
- cellular response to lipopolysaccharide [ISS]
- cellular response to organic cyclic compound [IDA]
- cellular response to tumor necrosis factor [IEP, ISS]
- chemotaxis [TAS]
- cytokine-mediated signaling pathway [IDA]
- cytoskeleton organization [IDA]
- endoplasmic reticulum unfolded protein response [TAS]
- helper T cell extravasation [ISS]
- humoral immune response [TAS]
- inflammatory response [IDA]
- lipopolysaccharide-mediated signaling pathway [IDA]
- macrophage chemotaxis [IDA]
- monocyte chemotaxis [IDA]
- negative regulation of glial cell apoptotic process [IDA]
- negative regulation of natural killer cell chemotaxis [IDA]
- negative regulation of neuron apoptotic process [IDA]
- organ morphogenesis [TAS]
- positive regulation of T cell activation [ISS]
- positive regulation of apoptotic cell clearance [ISS]
- positive regulation of calcium ion import [IDA]
- positive regulation of nitric-oxide synthase biosynthetic process [ISS]
- protein kinase B signaling [IMP]
- protein phosphorylation [TAS]
- regulation of cell shape [IDA]
- response to bacterium [IEP]
- signal transduction [NAS]
- viral genome replication [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PCA
A Protein-Fragment Complementation Assay (PCA) is a protein-protein interaction assay in which a bait protein is expressed as fusion to one of the either N- or C- terminal peptide fragments of a reporter protein and prey protein is expressed as fusion to the complementary N- or C- terminal fragment of the same reporter protein. Interaction of bait and prey proteins bring together complementary fragments, which can then fold into an active reporter, e.g. the split-ubiquitin assay.
Publication
Identification of the Tetraspanin CD9 as an Interaction Partner of Organic Cation Transporters 1 and 2.
Organic cation transporters (OCTs) are membrane proteins with relevant physiological (because they accept neurotransmitters as substrate) and pharmacological (because of their interaction with drugs) roles. The human OCTs hOCT1 (SLC22A1/hOCT1) and hOCT2 (SLC22A2/hOCT2) are highly expressed in hepatic (hOCT1) and in renal and neuronal tissue (hOCT2), suggesting a possible role in modulating neurotransmitter activity in the liver, kidney, and brain, ... [more]
Throughput
- High Throughput
Curated By
- BioGRID