GABBR2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GABBR1
Gene Ontology Biological Process
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [ISO]
- gamma-aminobutyric acid signaling pathway [IDA, ISO]
- negative regulation of adenylate cyclase activity [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of dopamine secretion [ISO]
- negative regulation of epinephrine secretion [ISO]
- negative regulation of gamma-aminobutyric acid secretion [ISO]
- negative regulation of synaptic transmission [ISO]
- osteoblast differentiation [ISO]
- positive regulation of glutamate secretion [ISO]
- positive regulation of growth hormone secretion [ISO]
- regulation of cAMP biosynthetic process [ISO]
- regulation of glutamate secretion [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- G-protein coupled receptor dimeric complex [IDA]
- G-protein coupled receptor heterodimeric complex [ISO]
- axolemma [ISO]
- cytoplasm [IDA]
- dendritic shaft [ISO]
- dendritic spine [ISO]
- endoplasmic reticulum membrane [ISO]
- extracellular space [ISO]
- integral component of plasma membrane [ISO]
- intracellular membrane-bounded organelle [ISO]
- membrane [IDA]
- membrane raft [ISO]
- mitochondrial membrane [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- postsynaptic membrane [IDA]
- presynaptic membrane [IDA]
- synaptic vesicle [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity.
G protein-coupled receptors are commonly thought to bind their cognate ligands and elicit functional responses primarily as monomeric receptors. In studying the recombinant gamma-aminobutyric acid, type B (GABAB) receptor (gb1a) and a GABAB-like orphan receptor (gb2), we observed that both receptors are functionally inactive when expressed individually in multiple heterologous systems. Characterization of the tissue distribution of each of the ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GABBR1 GABBR2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID