BAIT
LHX3
CPHD3, LIM3, M2-LHX3
LIM homeobox 3
GO Process (3)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
Homo sapiens
PREY
ANP32A
C15orf1, HPPCn, I1PP2A, LANP, MAPM, PHAP1, PHAPI, PP32
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
GO Process (5)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
LHX3 interacts with inhibitor of histone acetyltransferase complex subunits LANP and TAF-1? to modulate pituitary gene regulation.
LIM-homeodomain 3 (LHX3) is a transcription factor required for mammalian pituitary gland and nervous system development. Human patients and animal models with LHX3 gene mutations present with severe pediatric syndromes that feature hormone deficiencies and symptoms associated with nervous system dysfunction. The carboxyl terminus of the LHX3 protein is required for pituitary gene regulation, but the mechanism by which this ... [more]
PLoS ONE Jul. 19, 2013; 8(7);e68898 [Pubmed: 23861948]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LHX3 ANP32A | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID