SCN1B
Gene Ontology Biological Process
- axon guidance [ISS, TAS]
- cardiac conduction [ISS]
- cardiac muscle cell action potential involved in contraction [IMP]
- cardiac muscle contraction [IMP]
- corticospinal neuron axon guidance [ISS]
- locomotion [ISS]
- membrane depolarization [IDA]
- membrane depolarization during Purkinje myocyte cell action potential [IMP]
- membrane depolarization during cardiac muscle cell action potential [ISS]
- neuronal action potential propagation [ISS]
- positive regulation of neuron projection development [ISS]
- positive regulation of sodium ion transport [IDA]
- regulation of atrial cardiac muscle cell membrane depolarization [IMP]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of sodium ion transmembrane transporter activity [IDA]
- regulation of ventricular cardiac muscle cell membrane repolarization [ISS]
- sodium ion transmembrane transport [IDA, IMP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function- sodium channel inhibitor activity [ISS]
- sodium channel regulator activity [IDA]
- voltage-gated sodium channel activity [IDA]
- voltage-gated sodium channel activity involved in Purkinje myocyte action potential [IMP]
- voltage-gated sodium channel activity involved in cardiac muscle cell action potential [IMP]
- sodium channel inhibitor activity [ISS]
- sodium channel regulator activity [IDA]
- voltage-gated sodium channel activity [IDA]
- voltage-gated sodium channel activity involved in Purkinje myocyte action potential [IMP]
- voltage-gated sodium channel activity involved in cardiac muscle cell action potential [IMP]
Gene Ontology Cellular Component
SCN4B
Gene Ontology Biological Process
- AV node cell to bundle of His cell communication [IMP]
- cardiac muscle cell action potential involved in contraction [IMP]
- cardiac muscle contraction [IMP]
- membrane depolarization during cardiac muscle cell action potential [IMP]
- positive regulation of sodium ion transport [IDA]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of sodium ion transmembrane transporter activity [IDA]
- regulation of ventricular cardiac muscle cell membrane repolarization [IMP]
- sodium ion transmembrane transport [IDA]
- sodium ion transport [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Regulation of persistent Na current by interactions between beta subunits of voltage-gated Na channels.
The beta subunits of voltage-gated Na channels (Scnxb) regulate the gating of pore-forming alpha subunits, as well as their trafficking and localization. In heterologous expression systems, beta1, beta2, and beta3 subunits influence inactivation and persistent current in different ways. To test how the beta4 protein regulates Na channel gating, we transfected beta4 into HEK (human embryonic kidney) cells stably expressing ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID