BAIT

DRD2

D2DR, D2R
dopamine receptor D2
GO Process (54)
GO Function (5)
GO Component (4)

Gene Ontology Biological Process

Homo sapiens

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

Dynamin-2 associates with the dopamine receptor signalplex and regulates internalization of activated D2 receptors.

Kabbani N, Jeromin A, Levenson R

Dopamine receptors (DRs) are implicated in modulating a variety of important neuronal processes including those involved in development and plasticity. Although dopamine receptors are known to be internalized in response to ligand activation, the mechanisms regulating this process have not been clearly defined. Here, we show that D2 dopamine receptors (D2Rs) undergo dynamin-2-dependent internalization in response to agonist treatment. Using ... [more]

Cell. Signal. Apr. 01, 2004; 16(4);497-503 [Pubmed: 14709338]

Throughput

  • Low Throughput

Curated By

  • BioGRID