SLC6A4
Gene Ontology Biological Process
- brain development [IEP]
- brain morphogenesis [ISO]
- cellular response to cGMP [IDA]
- cellular response to organic substance [ISO]
- cellular response to retinoic acid [IEP]
- circadian rhythm [IMP]
- locomotory behavior [NAS]
- memory [IMP]
- monoamine transport [ISO]
- negative regulation of cerebellar granule cell precursor proliferation [IMP]
- negative regulation of neuron differentiation [IMP]
- negative regulation of organ growth [ISO]
- negative regulation of synaptic transmission, dopaminergic [IMP]
- positive regulation of cell cycle [ISO]
- positive regulation of gene expression [ISO]
- protein homooligomerization [IDA]
- protein oligomerization [IDA]
- response to drug [IEP]
- response to estradiol [IEP]
- response to hypoxia [IEP]
- response to nutrient [IEP]
- response to organic substance [IEP]
- response to toxic substance [ISO]
- serotonin transport [IDA, IMP, ISO, TAS]
- serotonin uptake [IDA, IMP, ISO]
- social behavior [ISO]
- sperm ejaculation [IMP]
- thalamus development [ISO]
- vasoconstriction [IMP]
Gene Ontology Molecular Function- Rab GTPase binding [ISO]
- actin filament binding [IDA]
- cocaine binding [IMP]
- monoamine transmembrane transporter activity [ISO]
- myosin binding [IPI]
- nitric-oxide synthase binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IMP]
- serotonin transmembrane transporter activity [IDA, IMP, ISO, ISS, TAS]
- serotonin:sodium symporter activity [ISO, ISS]
- syntaxin-1 binding [IPI]
- Rab GTPase binding [ISO]
- actin filament binding [IDA]
- cocaine binding [IMP]
- monoamine transmembrane transporter activity [ISO]
- myosin binding [IPI]
- nitric-oxide synthase binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IMP]
- serotonin transmembrane transporter activity [IDA, IMP, ISO, ISS, TAS]
- serotonin:sodium symporter activity [ISO, ISS]
- syntaxin-1 binding [IPI]
Gene Ontology Cellular Component
GPM6B
Gene Ontology Biological Process
- extracellular matrix assembly [ISO, ISS]
- negative regulation of protein localization to cell surface [ISO, ISS]
- negative regulation of serotonin uptake [ISO, ISS]
- positive regulation of bone mineralization [ISO, ISS]
- regulation of actin cytoskeleton organization [ISO, ISS]
- regulation of focal adhesion assembly [ISO, ISS]
Gene Ontology Cellular Component
- membrane raft [ISO, ISS]
- plasma membrane [ISO, ISS]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Membrane glycoprotein M6B interacts with the human serotonin transporter.
The serotonin transporter (SERT) belongs to a family of sodium- and chloride-dependent neurotransmitter transporters that are responsible for the active re-uptake of the neurotransmitter serotonin from the synapse. In the present study, using the yeast two-hybrid system, we identified the membrane glycoprotein M6B as a binding partner of SERT. This interaction was further verified by co-immunoprecipitation and glutathione-S-transferase pull-down assays. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID