BAIT
FHL1
FHL-1, FHL1A, FHL1B, FLH1A, KYOT, SLIM, SLIM-1, SLIM1, SLIMMER, XMPMA, RP11-535K18.1
four and a half LIM domains 1
GO Process (8)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- muscle organ development [NAS]
- negative regulation of G1/S transition of mitotic cell cycle [IDA]
- negative regulation of G2/M transition of mitotic cell cycle [IDA]
- negative regulation of cell growth [IDA]
- organ morphogenesis [NAS]
- positive regulation of potassium ion transport [IDA]
- regulation of membrane depolarization [IDA]
- regulation of potassium ion transmembrane transporter activity [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CSRP3
CLP, CMD1M, CMH12, CRP3, LMO4, MLP
cysteine and glycine-rich protein 3 (cardiac LIM protein)
GO Process (9)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
- cardiac muscle contraction [IMP]
- cardiac muscle hypertrophy [IMP]
- cardiac muscle tissue development [ISS]
- cardiac myofibril assembly [ISS]
- cellular calcium ion homeostasis [ISS]
- detection of muscle stretch [IMP]
- protein localization to organelle [IMP]
- regulation of the force of heart contraction [ISS]
- skeletal muscle tissue development [TAS]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
The complexity of the skeletal muscle and the identification of numerous human disease-causing mutations in its constitutive proteins make it an interesting tissue for proteomic studies aimed at understanding functional relationships of interacting proteins in both health and diseases.We undertook a large-scale study using two-hybrid screens and a human skeletal-muscle cDNA library to establish a proteome-scale map of protein-protein interactions ... [more]
Skelet Muscle Feb. 19, 2013; 3(1);3 [Pubmed: 23414517]
Throughput
- High Throughput
Curated By
- BioGRID