BAIT
LIMS1
PINCH, PINCH-1, PINCH1
LIM and senescent cell antigen-like domains 1
GO Process (12)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- cell aging [TAS]
- cell junction assembly [TAS]
- cellular response to transforming growth factor beta stimulus [IEP]
- epithelial to mesenchymal transition [IMP]
- establishment of protein localization [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of GTPase activity [IMP]
- positive regulation of cell-substrate adhesion [IMP]
- positive regulation of focal adhesion assembly [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of substrate adhesion-dependent cell spreading [IMP]
- regulation of epithelial cell proliferation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TRIO
ARHGEF23, tgat
trio Rho guanine nucleotide exchange factor
GO Process (8)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- apoptotic signaling pathway [TAS]
- axon guidance [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of GTPase activity [TAS]
- positive regulation of apoptotic process [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- transmembrane receptor protein tyrosine phosphatase signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
The complexity of the skeletal muscle and the identification of numerous human disease-causing mutations in its constitutive proteins make it an interesting tissue for proteomic studies aimed at understanding functional relationships of interacting proteins in both health and diseases.We undertook a large-scale study using two-hybrid screens and a human skeletal-muscle cDNA library to establish a proteome-scale map of protein-protein interactions ... [more]
Skelet Muscle Feb. 19, 2013; 3(1);3 [Pubmed: 23414517]
Throughput
- High Throughput
Curated By
- BioGRID