FAS
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- apoptotic process [IDA, TAS]
- apoptotic signaling pathway [TAS]
- cellular response to hyperoxia [IMP]
- cellular response to mechanical stimulus [IEP]
- extrinsic apoptotic signaling pathway [IMP]
- necroptotic signaling pathway [IMP]
- positive regulation of apoptotic process [IDA, IMP]
- protein complex assembly [TAS]
- regulation of apoptotic process [NAS]
- regulation of extrinsic apoptotic signaling pathway in absence of ligand [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PEA15
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Human astrocytes are resistant to Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.
Human astrocytes express Fas yet are resistant to Fas-induced apoptosis. Here, we report that calcium/calmodulin-dependent protein kinase II (CaMKII) is constitutively activated in human astrocytes and protects the cells from apoptotic stimulation by Fas agonist. Once stimulated, Fas recruits Fas-associated death domain and caspase-8 for the assembly of the death-inducing signaling complex (DISC); however, caspase-8 cleavage is inhibited in the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID