BAIT
HSCB
DNAJC20, HSC20, JAC1, dJ366L4.2, RP3-366L4.2
HscB mitochondrial iron-sulfur cluster co-chaperone
GO Process (1)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ITGB1
CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB, RP11-479G22.2
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
GO Process (25)
GO Function (6)
GO Component (21)
Gene Ontology Biological Process
- B cell differentiation [IC]
- axon guidance [TAS]
- blood coagulation [TAS]
- calcium-independent cell-matrix adhesion [IGI]
- cell junction assembly [TAS]
- cell migration [TAS]
- cell-cell adhesion mediated by integrin [IEP]
- cell-matrix adhesion [IMP]
- cell-substrate adhesion [IMP]
- cellular defense response [TAS]
- extracellular matrix organization [TAS]
- heterotypic cell-cell adhesion [IMP]
- homophilic cell adhesion via plasma membrane adhesion molecules [TAS]
- integrin-mediated signaling pathway [IMP]
- leukocyte cell-cell adhesion [IDA]
- leukocyte migration [TAS]
- leukocyte tethering or rolling [IMP]
- mesodermal cell differentiation [IEP]
- negative regulation of anoikis [IMP]
- positive regulation of apoptotic process [IGI]
- positive regulation of establishment of protein localization to plasma membrane [IDA]
- regulation of collagen catabolic process [IDA]
- regulation of immune response [TAS]
- stress fiber assembly [IMP]
- transforming growth factor beta receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell surface [IDA]
- cytoplasm [IDA]
- extracellular vesicular exosome [IDA]
- filopodium [IDA]
- focal adhesion [IDA]
- integrin alpha1-beta1 complex [IDA]
- integrin alpha10-beta1 complex [IDA]
- integrin alpha11-beta1 complex [IDA]
- integrin alpha2-beta1 complex [IDA]
- integrin alpha3-beta1 complex [IDA]
- integrin alpha8-beta1 complex [TAS]
- integrin complex [NAS]
- invadopodium membrane [IDA]
- membrane [IDA]
- membrane raft [IDA]
- neuromuscular junction [IDA]
- plasma membrane [IDA, NAS, TAS]
- receptor complex [IDA]
- ruffle [TAS]
- ruffle membrane [IDA, NAS]
- sarcolemma [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.
The iron-sulfur (Fe-S) cluster of the Rieske protein, UQCRFS1, is essential for Complex III (CIII) activity, though the mechanism for Fe-S cluster transfer has not previously been elucidated. Recent studies have shown that the co-chaperone HSC20, essential for Fe-S cluster biogenesis of SDHB, directly binds LYRM7, formerly described as a chaperone that stabilizes UQCRFS1 prior to its insertion into CIII. ... [more]
Unknown Apr. 04, 2017; 25(4);945-953.e6 [Pubmed: 28380382]
Throughput
- High Throughput
Additional Notes
- endogenous HSC20 was immunoprecipitated from detergent extracts from organellar fractions and associated proteins were identified by mass spectrometry
Curated By
- BioGRID