NME1
Gene Ontology Biological Process
- DNA catabolic process [IDA]
- negative regulation of cell proliferation [TAS]
- nucleobase-containing small molecule interconversion [TAS]
- nucleobase-containing small molecule metabolic process [TAS]
- positive regulation of DNA binding [IDA]
- positive regulation of epithelial cell proliferation [IMP]
- regulation of apoptotic process [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
TERF1
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [IEP]
- age-dependent telomere shortening [IDA]
- mitotic spindle assembly checkpoint [IMP]
- negative regulation of DNA replication [IDA]
- negative regulation of telomerase activity [IGI]
- negative regulation of telomere maintenance via semi-conservative replication [NAS]
- negative regulation of telomere maintenance via telomerase [IGI]
- positive regulation of apoptotic process [IDA]
- positive regulation of microtubule polymerization [IDA]
- positive regulation of mitosis [IMP]
- positive regulation of mitotic cell cycle [IMP]
- protein homooligomerization [IDA]
- telomere maintenance [TAS]
- telomere maintenance via telomerase [IMP, NAS]
- telomeric loop formation [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Association of nucleoside diphosphate kinase nm23-H2 with human telomeres.
Telomeres, the ends of eukaryotic chromosomes, are essential structures formed by specific protein-DNA complexes that protect chromosomes from degradation and end-to-end fusion. TRF1, a double-stranded telomeric TTAGGG-repeat binding protein, is associated with mammalian telomeres and controls telomere length by inhibiting the action of telomerase. We identified human nucleoside diphosphate kinase nm23-H2 as a human TRF1-interacting protein by yeast two-hybrid screening. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TERF1 NME1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID