WNT3A
Gene Ontology Biological Process
- COP9 signalosome assembly [ISS]
- canonical Wnt signaling pathway [IDA]
- canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [IDA]
- cell proliferation in forebrain [ISS]
- cellular response to retinoic acid [ISS]
- negative regulation of heart induction by canonical Wnt signaling pathway [IDA]
- negative regulation of neurogenesis [ISS]
- negative regulation of neuron projection development [ISS]
- neuron differentiation [IBA, ISS]
- palate development [IMP]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cardiac muscle cell differentiation [IDA]
- positive regulation of catenin import into nucleus [IDA]
- positive regulation of cell proliferation [ISS]
- positive regulation of dermatome development [IDA]
- positive regulation of mesodermal cell fate specification [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of protein binding [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of receptor internalization [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FZD1
Gene Ontology Biological Process
- autocrine signaling [IDA]
- canonical Wnt signaling pathway [IDA]
- canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation [IMP]
- canonical Wnt signaling pathway involved in osteoblast differentiation [IMP]
- cell-cell signaling [IDA]
- neuron differentiation [ISS]
- non-canonical Wnt signaling pathway [IBA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- response to drug [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response.
The human homologue of fz1 (Hfz1) was cloned from a cDNA library. Hfz1 was shown to couple to Wnt signal transduction pathways by its ability to enhance Wnt induced TCF dependent transcription in both autocrine and paracrine modes. Enhanced TCF dependent signaling was dose dependent with respect to both Wnt-3A and Hfz1. Moreover, Hfz1 deletion mutants with truncated carboxy termini ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID