BAIT

TREML1

GLTL1825, PRO3438, TLT-1, TLT1, dJ238O23.3, UNQ1825/PRO3438

triggering receptor expressed on myeloid cells-like 1

GO Process (3)

GO Function (1)

GO Component (3)

Gene Ontology Biological Process

calcium-mediated signaling [IDA]

innate immune response [NAS]

platelet activation [IEP]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

cell surface [IDA]

integral component of membrane [NAS]

platelet alpha granule [IDA]

CRISPR Database VEGA HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

PTPN6

HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1

protein tyrosine phosphatase, non-receptor type 6

GO Process (22)

GO Function (4)

GO Component (6)

Gene Ontology Biological Process

G-protein coupled receptor signaling pathway [TAS]

JAK-STAT cascade involved in growth hormone signaling pathway [TAS]

T cell costimulation [TAS]

apoptotic process [TAS]

blood coagulation [TAS]

cell differentiation [IDA]

cell proliferation [IDA]

cytokine-mediated signaling pathway [TAS]

interferon-gamma-mediated signaling pathway [TAS]

leukocyte migration [TAS]

negative regulation of cell proliferation [NAS]

negative regulation of peptidyl-tyrosine phosphorylation [IMP]

peptidyl-tyrosine dephosphorylation [IDA, TAS]

peptidyl-tyrosine phosphorylation [IDA]

positive regulation of cell proliferation [IMP]

positive regulation of phosphatidylinositol 3-kinase signaling [IMP]

protein dephosphorylation [IDA]

regulation of ERK1 and ERK2 cascade [IDA]

regulation of G1/S transition of mitotic cell cycle [IMP]

regulation of interferon-gamma-mediated signaling pathway [TAS]

regulation of type I interferon-mediated signaling pathway [TAS]

type I interferon signaling pathway [TAS]

Gene Ontology Molecular Function

protein binding [IPI]
protein kinase binding [IPI]
protein tyrosine phosphatase activity [TAS]
transmembrane receptor protein tyrosine phosphatase activity [IDA]

Gene Ontology Cellular Component

cytoplasm [IDA]

extracellular vesicular exosome [IDA]

nucleolus [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

Initial characterization of TREM-like transcript (TLT)-1: a putative inhibitory receptor within the TREM cluster.

Washington AV, Quigley L, McVicar DW

The TREMs (triggering receptors expressed on myeloid cells) represent a family of 5 receptors clustered on murine chromosome 17. TREMs 1 and 2 affect various aspects of myeloid cell activation and development, including responsiveness to lipopolysaccharide and regulation of dendritic cell maturation, yet no inhibitory receptor has been demonstrated within this cluster. Here we characterize TLT-1 (TREM-like transcript-1), a putative ... [more]

Blood Nov. 15, 2002; 100(10);3822-4 [Pubmed: 12393607]

Throughput

Low Throughput

Curated By

BioGRID