SERPINA5
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- acrosomal membrane [IDA]
- external side of plasma membrane [IDA]
- extracellular region [IBA, NAS, TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- membrane [IDA]
- platelet alpha granule [IDA]
- platelet dense tubular network [IDA]
- protein C inhibitor-KLK3 complex [IDA]
- protein C inhibitor-PLAT complex [IDA]
- protein C inhibitor-PLAU complex [IDA]
- protein C inhibitor-TMPRSS11E complex [IDA]
- protein C inhibitor-TMPRSS7 complex [IDA]
- protein C inhibitor-coagulation factor V complex [IDA]
- protein C inhibitor-coagulation factor XI complex [IDA]
- protein C inhibitor-coagulation factor Xa complex [IDA]
- protein C inhibitor-plasma kallikrein complex [IDA]
- protein C inhibitor-thrombin complex [IDA]
- protein complex [IDA]
PLAT
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Purification and characterization of plasma protein C inhibitor.
Plasma protein C inhibitor (PCI) was purified to homogeneity (greater than 95%) with good recovery (greater than 25%) and reproducibility, and the inhibition of a number of blood clotting and fibrinolytic enzymes by purified PCI was studied. PCI inhibited activated protein C (APC), two-chain urokinase (2c-uPA), two-chain tissue plasminogen activator (2c-tPA), thrombin, factor Xa, plasma kallikrein and factor XIa, and ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID