BAIT
JAK2
Fd17
Janus kinase 2
GO Process (80)
GO Function (17)
GO Component (8)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- JAK-STAT cascade [IDA, IMP, ISO]
- JAK-STAT cascade involved in growth hormone signaling pathway [IDA, IMP, ISO]
- STAT protein import into nucleus [IDA]
- activation of JAK2 kinase activity [IDA]
- activation of MAPKK activity [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [IDA]
- axon regeneration [ISO]
- cell differentiation [IMP]
- cell migration [IBA]
- cellular response to dexamethasone stimulus [IDA]
- cellular response to lipopolysaccharide [IDA]
- cytokine-mediated signaling pathway [IMP, ISO, TAS]
- enzyme linked receptor protein signaling pathway [IDA]
- erythrocyte differentiation [IMP]
- extrinsic apoptotic signaling pathway [IDA]
- growth hormone receptor signaling pathway [ISO]
- histone H3-Y41 phosphorylation [IBA, ISO]
- hormone-mediated signaling pathway [ISO]
- host programmed cell death induced by symbiont [IDA]
- inflammatory response [IBA]
- innate immune response [IBA]
- interferon-gamma-mediated signaling pathway [ISO]
- interleukin-12-mediated signaling pathway [ISO]
- intracellular signal transduction [IDA]
- intrinsic apoptotic signaling pathway in response to oxidative stress [ISO]
- mammary gland epithelium development [IMP]
- mineralocorticoid receptor signaling pathway [ISO]
- myeloid cell differentiation [IMP]
- negative regulation of DNA binding [IDA]
- negative regulation of apoptotic process [IDA]
- negative regulation of cardiac muscle cell apoptotic process [ISO]
- negative regulation of cell proliferation [IMP]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of heart contraction [ISO]
- negative regulation of neuron apoptotic process [ISO]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA]
- platelet-derived growth factor receptor signaling pathway [ISO]
- positive regulation of DNA binding [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of apoptotic signaling pathway [IMP]
- positive regulation of cell activation [ISO]
- positive regulation of cell differentiation [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of growth hormone receptor signaling pathway [IMP]
- positive regulation of inflammatory response [ISO]
- positive regulation of insulin secretion [ISO]
- positive regulation of interleukin-1 beta production [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of nitric-oxide synthase biosynthetic process [IDA, ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of phosphoprotein phosphatase activity [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of tumor necrosis factor production [IDA]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IDA]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IDA]
- protein autophosphorylation [IDA, ISO]
- regulation of cell adhesion [IBA]
- regulation of inflammatory response [ISO]
- response to antibiotic [ISO]
- response to granulocyte macrophage colony-stimulating factor [NAS]
- response to hydroperoxide [ISO]
- response to interleukin-12 [ISO]
- response to lipopolysaccharide [IDA]
- response to oxidative stress [ISO]
- response to tumor necrosis factor [ISO]
- signal transduction [IMP]
- tumor necrosis factor-mediated signaling pathway [ISO]
- tyrosine phosphorylation of STAT protein [IDA, IMP]
- tyrosine phosphorylation of Stat1 protein [ISO]
- tyrosine phosphorylation of Stat3 protein [ISO]
- tyrosine phosphorylation of Stat5 protein [ISO]
Gene Ontology Molecular Function- SH2 domain binding [ISO]
- acetylcholine receptor binding [ISO]
- growth hormone receptor binding [IBA, ISO]
- heme binding [ISO]
- histone binding [ISO]
- histone kinase activity (H3-Y41 specific) [IBA, ISO]
- insulin receptor substrate binding [ISO]
- interleukin-12 receptor binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- peptide hormone receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IDA, IMP, ISO]
- receptor binding [ISO]
- type 1 angiotensin receptor binding [ISO]
- SH2 domain binding [ISO]
- acetylcholine receptor binding [ISO]
- growth hormone receptor binding [IBA, ISO]
- heme binding [ISO]
- histone binding [ISO]
- histone kinase activity (H3-Y41 specific) [IBA, ISO]
- insulin receptor substrate binding [ISO]
- interleukin-12 receptor binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- peptide hormone receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IDA, IMP, ISO]
- receptor binding [ISO]
- type 1 angiotensin receptor binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
KIT
Bs, CD117, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, SCO1, SCO5, SOW3, Ssm, Tr-kit, W, c-KIT
kit oncogene
GO Process (66)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- Fc receptor signaling pathway [ISO]
- Kit signaling pathway [IDA, ISO]
- T cell differentiation [IMP]
- actin cytoskeleton reorganization [ISO]
- activation of MAPK activity [ISO]
- cell chemotaxis [ISO]
- cell differentiation [TAS]
- cellular response to thyroid hormone stimulus [IDA]
- chemotaxis [TAS]
- cytokine-mediated signaling pathway [IDA, ISO]
- dendritic cell cytokine production [IMP]
- detection of mechanical stimulus involved in sensory perception of sound [IMP]
- developmental pigmentation [IMP]
- digestive tract development [IMP]
- ectopic germ cell programmed cell death [IGI]
- embryonic hemopoiesis [IMP]
- epithelial cell proliferation [ISO]
- erythrocyte differentiation [IMP]
- erythropoietin-mediated signaling pathway [IMP]
- germ cell development [TAS]
- germ cell migration [ISO]
- glycosphingolipid metabolic process [IMP]
- hemopoiesis [IMP]
- immature B cell differentiation [IMP]
- inflammatory response [IMP]
- intracellular signal transduction [IDA]
- lamellipodium assembly [IDA]
- lymphoid progenitor cell differentiation [IGI]
- mast cell chemotaxis [ISO]
- mast cell cytokine production [ISO]
- mast cell degranulation [ISO]
- mast cell differentiation [IMP]
- megakaryocyte development [IMP]
- melanocyte adhesion [IDA]
- melanocyte differentiation [IMP]
- melanocyte migration [IMP]
- myeloid leukocyte differentiation [IMP]
- myeloid progenitor cell differentiation [IGI]
- negative regulation of programmed cell death [IGI, IMP]
- ovarian follicle development [IMP]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- pigmentation [IGI, IMP]
- positive regulation of JAK-STAT cascade [ISO]
- positive regulation of MAP kinase activity [IGI]
- positive regulation of MAPK cascade [ISO]
- positive regulation of Notch signaling pathway [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [IGI, ISO]
- positive regulation of gene expression [IMP]
- positive regulation of long-term neuronal synaptic plasticity [ISO]
- positive regulation of pseudopodium assembly [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of tyrosine phosphorylation of Stat1 protein [ISO]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISO]
- positive regulation of tyrosine phosphorylation of Stat5 protein [ISO]
- protein autophosphorylation [ISO, TAS]
- protein phosphorylation [IDA]
- regulation of cell shape [IDA]
- regulation of developmental pigmentation [IGI, IMP]
- response to radiation [IMP]
- somatic stem cell division [ISO]
- somatic stem cell maintenance [ISO]
- spermatid development [IMP]
- spermatogenesis [IMP, ISO]
- stem cell differentiation [IMP]
- visual learning [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor.
Stem cell factor (SCF) is a hematopoietic growth factor that interacts with the receptor tyrosine kinase, c-kit. We have found that SCF-stimulates rapid and transient tyrosine phosphorylation of JAK2 in human and murine cell lines, as well as in normal human progenitor cells. JAK2 and c-kit were associated in unstimulated cells with further recruitment of JAK2 to the c-kit receptor ... [more]
Blood May. 01, 1996; 87(9);3688-93 [Pubmed: 8611693]
Throughput
- Low Throughput
Curated By
- BioGRID