CRKL
Gene Ontology Biological Process
Gene Ontology Molecular Function
BCAR1
Gene Ontology Biological Process
- B cell receptor signaling pathway [IDA]
- G-protein coupled receptor signaling pathway [ISS, NAS]
- T cell receptor signaling pathway [NAS]
- actin filament organization [IDA]
- antigen receptor-mediated signaling pathway [IDA]
- blood coagulation [TAS]
- cell chemotaxis [IMP]
- cell division [NAS]
- cell migration [IDA]
- cell proliferation [TAS]
- cellular response to hepatocyte growth factor stimulus [IMP]
- epidermal growth factor receptor signaling pathway [ISS]
- hepatocyte growth factor receptor signaling pathway [IMP]
- insulin receptor signaling pathway [ISS]
- integrin-mediated signaling pathway [IDA]
- neurotrophin TRK receptor signaling pathway [ISS]
- platelet activation [TAS]
- platelet-derived growth factor receptor signaling pathway [ISS]
- positive regulation of cell migration [IDA]
- positive regulation of endothelial cell migration [IDA]
- regulation of apoptotic process [TAS]
- regulation of cell growth [TAS]
- vascular endothelial growth factor receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cells.
CrkL, a cellular homologue of the v-crk oncogene, belongs to the family of adaptor proteins, containing SH2 and SH3 domains, but no catalytic domain. Stimulation of normal B-cells and B-cell lines through beta1 integrin or - cell antigen receptor (BCR) promoted the association of CrkL with a set of 105-130 kD tyrosine phosphorylated substrates. The principal substrate is a recently ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BCAR1 CRKL | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| BCAR1 CRKL | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 244718 | |
| BCAR1 CRKL | Far Western Far Western An interaction is detected between a protein immobilized on a membrane and a purified protein probe. | Low | - | BioGRID | 244717 | |
| BCAR1 CRKL | Protein-peptide Protein-peptide An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments. | Low | - | BioGRID | - |
Curated By
- BioGRID