BAIT
SMG6
C17orf31, EST1A, SMG-6, hSMG5/7a
SMG6 nonsense mediated mRNA decay factor
GO Process (8)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- RNA phosphodiester bond hydrolysis, endonucleolytic [IDA, IMP, TAS]
- gene expression [TAS]
- mRNA export from nucleus [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [IMP, TAS]
- regulation of dephosphorylation [TAS]
- telomere maintenance [IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
BCR
ALL, BCR1, CML, D22S11, D22S662, PHL
breakpoint cluster region
GO Process (5)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies.
mRNA processing, transport, translation, and ultimately degradation involve a series of dedicated protein complexes that often assemble into large membraneless structures such as stress granules (SGs) and processing bodies (PBs). Here, systematic in vivo proximity-dependent biotinylation (BioID) analysis of 119 human proteins associated with different aspects of mRNA biology uncovers 7424 unique proximity interactions with 1,792 proteins. Classical bait-prey analysis reveals ... [more]
Mol. Cell Dec. 01, 2017; 69(3);517-532.e11 [Pubmed: 29395067]
Throughput
- Low Throughput
Additional Notes
- BioID
- High confidence interactions had a SAINTexpress score or AvgP >= 0.95.
Curated By
- BioGRID