PIN1
Gene Ontology Biological Process
- cytokine-mediated signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of cell motility [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA]
- negative regulation of type I interferon production [TAS]
- positive regulation of Rho GTPase activity [IMP]
- positive regulation of protein phosphorylation [IGI]
- positive regulation of ubiquitin-protein transferase activity [IDA]
- protein peptidyl-prolyl isomerization [IDA]
- regulation of cytokinesis [IGI, IMP]
- regulation of mitosis [TAS]
- regulation of pathway-restricted SMAD protein phosphorylation [IDA]
Gene Ontology Molecular Function
NFATC2
Gene Ontology Biological Process
- B cell receptor signaling pathway [IMP]
- Fc-epsilon receptor signaling pathway [TAS]
- cell migration [IDA]
- cellular response to DNA damage stimulus [IMP]
- innate immune response [TAS]
- positive regulation of B cell proliferation [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of transcription, DNA-templated [TAS]
- response to drug [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [IDA]
- cytoplasm [IDA, TAS]
- cytosol [TAS]
- nucleoplasm [IDA, TAS]
- nucleus [IDA, TAS]
- plasma membrane [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Binding and regulation of the transcription factor NFAT by the peptidyl prolyl cis-trans isomerase Pin1.
Nuclear factor of activated T cells (NFAT) plays a key role in T cell activation. The activation of NFAT involves calcium- and calcineurin-dependent dephosphorylation and nuclear translocation from the cytoplasm, a process that is opposed by protein kinases. We show here that the peptidyl prolyl cis-trans isomerase Pin1 interacts specifically with the phosphorylated form of NFAT. The NFAT-Pin1 interaction is ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID