F7
Gene Ontology Biological Process
- blood coagulation [TAS]
- blood coagulation, extrinsic pathway [TAS]
- cellular protein metabolic process [TAS]
- peptidyl-glutamic acid carboxylation [TAS]
- positive regulation of cell migration [TAS]
- positive regulation of leukocyte chemotaxis [IDA]
- positive regulation of platelet-derived growth factor receptor signaling pathway [IDA]
- positive regulation of positive chemotaxis [IDA]
- positive regulation of protein kinase B signaling [IDA]
- post-translational protein modification [TAS]
- proteolysis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
F3
Gene Ontology Biological Process
- activation of blood coagulation via clotting cascade [IC]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- activation of plasma proteins involved in acute inflammatory response [IDA]
- blood coagulation [TAS]
- blood coagulation, extrinsic pathway [TAS]
- cytokine-mediated signaling pathway [IBA]
- positive regulation of angiogenesis [IDA]
- positive regulation of cell migration [TAS]
- positive regulation of endothelial cell proliferation [IDA]
- positive regulation of platelet-derived growth factor receptor signaling pathway [IDA]
- positive regulation of positive chemotaxis [IC]
- positive regulation of protein kinase B signaling [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-crystal Structure
Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.
Publication
Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant.
The event that initiates the extrinsic pathway of blood coagulation is the association of coagulation factor VIIa (VIIa) with its cell-bound receptor, tissue factor (TF), exposed to blood circulation following tissue injury and/or vascular damage. The natural inhibitor of the TF.VIIa complex is the first Kunitz domain of tissue factor pathway inhibitor (TFPI-K1). The structure of TF. VIIa reversibly inhibited ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| F3 F7 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID