SLC8A1
Gene Ontology Biological Process
- blood coagulation [TAS]
- calcium ion export [IDA]
- calcium ion homeostasis [ISS]
- calcium ion import [IDA]
- calcium ion transport into cytosol [ISS]
- cardiac muscle cell development [ISS]
- cardiac muscle contraction [TAS]
- cell communication by electrical coupling involved in cardiac conduction [ISS]
- cellular response to caffeine [ISS]
- cellular response to reactive oxygen species [IDA]
- cellular sodium ion homeostasis [IDA]
- cytosolic calcium ion transport [TAS]
- ion transport [TAS]
- membrane depolarization during cardiac muscle cell action potential [TAS]
- muscle contraction [TAS]
- negative regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of the force of heart contraction [IMP]
- regulation of cardiac muscle contraction by calcium ion signaling [TAS]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [ISS, TAS]
- regulation of cell communication by electrical coupling [TAS]
- regulation of heart rate [ISS]
- regulation of the force of heart contraction [IC, ISS]
- relaxation of cardiac muscle [IC, TAS]
- relaxation of smooth muscle [ISS]
- response to muscle stretch [IMP]
- sodium ion export [IDA]
- sodium ion import [IDA]
- transmembrane transport [TAS]
- vascular smooth muscle contraction [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CAV3
Gene Ontology Biological Process
- T-tubule organization [TAS]
- caveola assembly [IDA]
- cell differentiation [ISS]
- cell growth [ISS]
- cholesterol homeostasis [ISS]
- endocytosis [ISS]
- glucose homeostasis [ISS]
- membrane raft organization [ISS]
- muscle cell cellular homeostasis [ISS]
- muscle organ development [TAS]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of MAPK cascade [ISS]
- negative regulation of calcium ion transport [IDA]
- negative regulation of cardiac muscle hypertrophy [IMP]
- negative regulation of cell size [IMP]
- negative regulation of nitric-oxide synthase activity [ISS]
- negative regulation of potassium ion transmembrane transport [ISS]
- negative regulation of potassium ion transmembrane transporter activity [ISS]
- negative regulation of protein kinase activity [ISS]
- negative regulation of protein localization to cell surface [NAS]
- negative regulation of sarcomere organization [IMP]
- plasma membrane organization [ISS]
- positive regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of microtubule polymerization [ISS]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [NAS]
- protein localization [ISS]
- protein localization to plasma membrane [ISS]
- regulation of calcium ion import [IDA]
- regulation of calcium ion transmembrane transporter activity [IDA]
- regulation of cardiac muscle contraction [IMP]
- regulation of heart contraction [ISS]
- regulation of heart rate [IMP]
- regulation of membrane depolarization during cardiac muscle cell action potential [IMP]
- regulation of membrane potential [IDA]
- regulation of nerve growth factor receptor activity [IMP]
- regulation of signal transduction by receptor internalization [IMP]
- regulation of skeletal muscle contraction [IMP]
- regulation of sodium ion transmembrane transporter activity [IDA]
- regulation of ventricular cardiac muscle cell membrane depolarization [IDA]
- regulation of ventricular cardiac muscle cell membrane repolarization [IMP]
- triglyceride metabolic process [ISS]
- ventricular cardiac muscle cell action potential [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Evidence for cardiac sodium-calcium exchanger association with caveolin-3.
The interaction of cardiac Na+-Ca2+ exchange (NCX1) with caveolin proteins was investigated in sarcolemmal vesicles. Western blots of sarcolemmal vesicles revealed the presence of caveolin-1, -2, and -3. NCX1 co-fractionated more closely with caveolin-3 than caveolin-1 on sucrose density gradients. NCX1 has five possible caveolin-binding motifs and NCX1 co-precipitated specifically with caveolin-3. Molecular sieve column chromatography indicated that this co-precipitation ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID