BAIT
FBXW7
AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
GO Process (24)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IDA]
- cellular response to DNA damage stimulus [IDA]
- cellular response to UV [IDA]
- lipid homeostasis [ISS]
- negative regulation of DNA endoreduplication [IMP]
- negative regulation of Notch signaling pathway [ISS]
- negative regulation of SREBP signaling pathway [ISS]
- negative regulation of hepatocyte proliferation [ISS]
- negative regulation of triglyceride biosynthetic process [ISS]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of epidermal growth factor-activated receptor activity [IDA]
- positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [IDA]
- positive regulation of proteasomal protein catabolic process [IDA]
- positive regulation of protein ubiquitination [IDA]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of ubiquitin-protein transferase activity [IDA]
- protein stabilization [IDA]
- protein ubiquitination [IDA]
- regulation of cell cycle G1/S phase transition [TAS]
- regulation of lipid storage [ISS]
- regulation of protein localization [ISS]
- sister chromatid cohesion [IMP]
- vasculature development [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SHC1
SHC, SHCA, RP11-307C12.1
SHC (Src homology 2 domain containing) transforming protein 1
GO Process (19)
GO Function (10)
GO Component (3)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [IDA]
- Ras protein signal transduction [TAS]
- activation of MAPK activity [IDA]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- blood coagulation [TAS]
- cellular protein metabolic process [TAS]
- endoplasmic reticulum unfolded protein response [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [IBA, ISS, TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine phosphorylation [TAS]
- platelet activation [TAS]
- positive regulation of DNA replication [ISS]
- positive regulation of cell proliferation [NAS]
- regulation of epidermal growth factor-activated receptor activity [TAS]
Gene Ontology Molecular Function- ephrin receptor binding [IPI]
- epidermal growth factor receptor binding [ISS]
- insulin receptor binding [IPI]
- insulin-like growth factor receptor binding [IPI]
- neurotrophin TRKA receptor binding [IPI]
- phospholipid binding [TAS]
- protein binding [IPI]
- protein kinase binding [IBA]
- protein tyrosine kinase activity [TAS]
- transmembrane receptor protein tyrosine kinase adaptor activity [TAS]
- ephrin receptor binding [IPI]
- epidermal growth factor receptor binding [ISS]
- insulin receptor binding [IPI]
- insulin-like growth factor receptor binding [IPI]
- neurotrophin TRKA receptor binding [IPI]
- phospholipid binding [TAS]
- protein binding [IPI]
- protein kinase binding [IBA]
- protein tyrosine kinase activity [TAS]
- transmembrane receptor protein tyrosine kinase adaptor activity [TAS]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Charting the molecular links between driver and susceptibility genes in colorectal cancer.
Despite significant advances in the identification of specific genes and pathways important in the onset and progression of colorectal cancer (CRC), mechanistic insight into the relationship between driver and susceptibility genes is needed. In this paper, we systematically explore physical interactions between causative and putative CRC susceptibility genes to reveal the molecular mechanisms involved in tumor biology. In total, we ... [more]
Unknown Mar. 21, 2014; 445(4);734-8 [Pubmed: 24412244]
Throughput
- High Throughput
Curated By
- BioGRID