BAIT
PTEN
10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
phosphatase and tensin homolog
GO Process (64)
GO Function (11)
GO Component (10)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell receptor signaling pathway [TAS]
- activation of mitotic anaphase-promoting complex activity [IDA]
- apoptotic process [ISS]
- brain morphogenesis [ISS]
- canonical Wnt signaling pathway [IDA]
- cell migration [ISS]
- cell proliferation [TAS]
- central nervous system development [ISS]
- central nervous system myelin maintenance [ISS]
- central nervous system neuron axonogenesis [ISS]
- dendritic spine morphogenesis [ISS]
- dentate gyrus development [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- forebrain morphogenesis [ISS]
- heart development [ISS]
- innate immune response [TAS]
- inositol phosphate dephosphorylation [IDA]
- inositol phosphate metabolic process [TAS]
- learning or memory [ISS]
- locomotor rhythm [ISS]
- locomotory behavior [ISS]
- multicellular organismal response to stress [ISS]
- negative regulation of G1/S transition of mitotic cell cycle [IDA]
- negative regulation of axonogenesis [ISS]
- negative regulation of cell migration [IMP]
- negative regulation of cell proliferation [IDA, IMP]
- negative regulation of cell size [ISS]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IDA]
- negative regulation of dendritic spine morphogenesis [ISS]
- negative regulation of excitatory postsynaptic membrane potential [ISS]
- negative regulation of focal adhesion assembly [IMP]
- negative regulation of organ growth [ISS]
- negative regulation of phosphatidylinositol 3-kinase signaling [TAS]
- negative regulation of protein kinase B signaling [IMP]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of synaptic vesicle clustering [ISS]
- neuron-neuron synaptic transmission [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine dephosphorylation [IDA]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol dephosphorylation [IDA, IMP]
- phosphatidylinositol-mediated signaling [TAS]
- phospholipid metabolic process [TAS]
- positive regulation of cell proliferation [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- postsynaptic density assembly [ISS]
- prepulse inhibition [ISS]
- presynaptic membrane assembly [ISS]
- protein dephosphorylation [IDA, TAS]
- protein kinase B signaling [ISS]
- protein stabilization [IDA]
- regulation of cellular component size [ISS]
- regulation of cyclin-dependent protein serine/threonine kinase activity [TAS]
- regulation of neuron projection development [ISS]
- regulation of protein stability [IMP]
- rhythmic synaptic transmission [ISS]
- small molecule metabolic process [TAS]
- social behavior [ISS]
- synapse assembly [ISS]
- synapse maturation [ISS]
Gene Ontology Molecular Function- PDZ domain binding [IPI]
- anaphase-promoting complex binding [IPI]
- enzyme binding [IPI]
- inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3-phosphatase activity [IDA]
- phosphoprotein phosphatase activity [IDA]
- protein binding [IPI]
- protein serine/threonine phosphatase activity [IDA]
- protein tyrosine phosphatase activity [IDA]
- PDZ domain binding [IPI]
- anaphase-promoting complex binding [IPI]
- enzyme binding [IPI]
- inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3-phosphatase activity [IDA]
- phosphoprotein phosphatase activity [IDA]
- protein binding [IPI]
- protein serine/threonine phosphatase activity [IDA]
- protein tyrosine phosphatase activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
TMEFF1
C9orf2, CT120.1, H7365, TR-1
transmembrane protein with EGF-like and two follistatin-like domains 1
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Charting the molecular links between driver and susceptibility genes in colorectal cancer.
Despite significant advances in the identification of specific genes and pathways important in the onset and progression of colorectal cancer (CRC), mechanistic insight into the relationship between driver and susceptibility genes is needed. In this paper, we systematically explore physical interactions between causative and putative CRC susceptibility genes to reveal the molecular mechanisms involved in tumor biology. In total, we ... [more]
Unknown Mar. 21, 2014; 445(4);734-8 [Pubmed: 24412244]
Throughput
- High Throughput
Curated By
- BioGRID