BAIT
DLC1
ARHGAP7, HP, STARD12, p122-RhoGAP
DLC1 Rho GTPase activating protein
GO Process (19)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- actin cytoskeleton organization [ISS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- apoptotic process [IDA]
- focal adhesion assembly [ISS]
- forebrain development [ISS]
- heart morphogenesis [ISS]
- hindbrain morphogenesis [ISS]
- negative regulation of Rho protein signal transduction [IMP]
- negative regulation of cell migration [IDA, IMP]
- negative regulation of cell proliferation [IDA, IMP]
- negative regulation of stress fiber assembly [IDA]
- neural tube closure [ISS]
- positive regulation of Rho GTPase activity [IDA, IMP]
- positive regulation of execution phase of apoptosis [IDA]
- positive regulation of protein dephosphorylation [IDA]
- regulation of actin cytoskeleton organization [IMP]
- regulation of cell shape [IMP]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
TMOD1
D9S57E, ETMOD, TMOD, RP11-244N9.1
tropomodulin 1
GO Process (4)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Charting the molecular links between driver and susceptibility genes in colorectal cancer.
Despite significant advances in the identification of specific genes and pathways important in the onset and progression of colorectal cancer (CRC), mechanistic insight into the relationship between driver and susceptibility genes is needed. In this paper, we systematically explore physical interactions between causative and putative CRC susceptibility genes to reveal the molecular mechanisms involved in tumor biology. In total, we ... [more]
Unknown Mar. 21, 2014; 445(4);734-8 [Pubmed: 24412244]
Throughput
- High Throughput
Curated By
- BioGRID