BAIT

AXIN2

AXIL, ODCRCS

axin 2

GO Process (18)

GO Function (7)

GO Component (12)

Gene Ontology Biological Process

Wnt signaling pathway involved in somitogenesis [IBA]

cellular protein localization [IDA]

cellular response to organic cyclic compound [IBA]

dorsal/ventral axis specification [IBA]

intramembranous ossification [IBA]

mRNA stabilization [IMP]

maintenance of DNA repeat elements [IMP]

negative regulation of canonical Wnt signaling pathway [IDA, IMP]

negative regulation of catenin import into nucleus [IMP]

negative regulation of cell proliferation [IMP]

negative regulation of osteoblast differentiation [IBA]

odontogenesis [IMP]

positive regulation of GTPase activity [IBA]

positive regulation of cell death [IMP]

positive regulation of epithelial to mesenchymal transition [IMP]

positive regulation of protein phosphorylation [IMP]

regulation of centromeric sister chromatid cohesion [IMP]

regulation of mismatch repair [IMP]

Gene Ontology Molecular Function

GTPase activator activity [IBA]
armadillo repeat domain binding [IBA]
beta-catenin binding [IBA, NAS]
enzyme binding [IPI]
protein binding [IPI]
protein kinase binding [IBA]
ubiquitin protein ligase binding [IPI]

Gene Ontology Cellular Component

Golgi apparatus [IDA]

beta-catenin destruction complex [NAS]

cell cortex [IBA]

centrosome [IDA]

cytoplasm [IDA]

cytoplasmic membrane-bounded vesicle [IBA]

cytoplasmic microtubule [IBA]

microtubule cytoskeleton [IDA]

nucleoplasm [IDA]

plasma membrane [IBA]

postsynaptic density [IBA]

CRISPR Database OMIM VEGA HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

RANGAP1

Fug1, RANGAP, SD, RP4-756G23.7

Ran GTPase activating protein 1

GO Process (3)

GO Function (1)

GO Component (5)

Gene Ontology Biological Process

mitotic cell cycle [TAS]

negative regulation of protein export from nucleus [IDA]

positive regulation of Ran GTPase activity [TAS]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

cytoplasm [IDA]

kinetochore [IDA]

nuclear membrane [IDA]

nuclear pore [TAS]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Charting the molecular links between driver and susceptibility genes in colorectal cancer.

Arroyo R, Duran-Frigola M, Berenguer C, Soler-Lopez M, Aloy P

Despite significant advances in the identification of specific genes and pathways important in the onset and progression of colorectal cancer (CRC), mechanistic insight into the relationship between driver and susceptibility genes is needed. In this paper, we systematically explore physical interactions between causative and putative CRC susceptibility genes to reveal the molecular mechanisms involved in tumor biology. In total, we ... [more]

Unknown Mar. 21, 2014; 445(4);734-8 [Pubmed: 24412244]

Throughput

High Throughput

Curated By

BioGRID