BAIT
SFRP4
FRP-4, FRPHE, sFRP-4
secreted frizzled-related protein 4
GO Process (13)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- negative regulation of canonical Wnt signaling pathway [IDA, IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of sodium-dependent phosphate transport [IDA]
- non-canonical Wnt signaling pathway [IBA]
- phosphate ion homeostasis [IDA]
- positive regulation of apoptotic process [IMP]
- positive regulation of canonical Wnt signaling pathway [IGI]
- positive regulation of epidermal cell differentiation [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of keratinocyte apoptotic process [IDA]
- positive regulation of receptor internalization [IDA]
- response to hormone [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
AP2M1
AP50, CLAPM1, mu2
adaptor-related protein complex 2, mu 1 subunit
GO Process (11)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- axon guidance [TAS]
- clathrin-mediated endocytosis [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- membrane organization [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- negative regulation of protein localization to plasma membrane [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- regulation of defense response to virus by virus [TAS]
- synaptic transmission [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Charting the molecular links between driver and susceptibility genes in colorectal cancer.
Despite significant advances in the identification of specific genes and pathways important in the onset and progression of colorectal cancer (CRC), mechanistic insight into the relationship between driver and susceptibility genes is needed. In this paper, we systematically explore physical interactions between causative and putative CRC susceptibility genes to reveal the molecular mechanisms involved in tumor biology. In total, we ... [more]
Unknown Mar. 21, 2014; 445(4);734-8 [Pubmed: 24412244]
Throughput
- High Throughput
Curated By
- BioGRID