BAIT

LRRC31

HEL-S-293, UNQ9367/PRO34156
leucine rich repeat containing 31
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

CLTC

CHC, CHC17, CLH-17, CLTCL2, Hc
clathrin, heavy chain (Hc)
Autophagy Project
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

Chen Y, Jiang T, Zhang H, Gou X, Han C, Wang J, Chen AT, Ma J, Liu J, Chen Z, Jing X, Lei H, Wang Z, Bao Y, Baqri M, Zhu Y, Bindra RS, Hansen JE, Dou J, Huang C, Zhou J

Breast cancer brain metastasis (BCBM) is a devastating disease. Radiation therapy remains the mainstay for treatment of this disease. Unfortunately, its efficacy is limited by the dose that can be safely applied. One promising approach to overcoming this limitation is to sensitize BCBMs to radiation by inhibiting their ability to repair DNA damage. Here, we report a DNA repair suppressor, ... [more]

Unknown Oct. 01, 2020; 22(10);1276-1285 [Pubmed: 33005030]

Throughput

  • High Throughput

Curated By

  • BioGRID