RPS6KA1
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- axon guidance [TAS]
- innate immune response [TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of cell differentiation [TAS]
- positive regulation of cell growth [TAS]
- positive regulation of hepatic stellate cell activation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of DNA-templated transcription in response to stress [TAS]
- regulation of translation in response to stress [TAS]
- signal transduction [TAS]
- stress-activated MAPK cascade [TAS]
- synaptic transmission [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
BAD
Gene Ontology Biological Process
- ADP metabolic process [ISS]
- ATP metabolic process [ISS]
- Fc-epsilon receptor signaling pathway [TAS]
- activation of cysteine-type endopeptidase activity [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]
- apoptotic process [IDA, TAS]
- apoptotic signaling pathway [TAS]
- cellular response to hypoxia [IEP]
- cellular response to mechanical stimulus [IEP]
- cellular response to nicotine [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- extrinsic apoptotic signaling pathway [IMP]
- fibroblast growth factor receptor signaling pathway [TAS]
- glucose homeostasis [ISS]
- innate immune response [TAS]
- intrinsic apoptotic signaling pathway [IMP, TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- pore complex assembly [IDA]
- positive regulation of apoptotic process [IDA, IMP, TAS]
- positive regulation of autophagy [TAS]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of glucokinase activity [ISS]
- positive regulation of insulin secretion [ISS]
- positive regulation of intrinsic apoptotic signaling pathway [TAS]
- positive regulation of mitochondrial membrane potential [ISS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- positive regulation of proteolysis [IDA]
- positive regulation of release of cytochrome c from mitochondria [IMP]
- positive regulation of type B pancreatic cell development [ISS]
- regulation of mitochondrial membrane permeability [IMP]
- type B pancreatic cell proliferation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.
Elongation factor 2 kinase (eEF2k) phosphorylates and inactivates eEF2. Insulin induces dephosphorylation of eEF2 and inactivation of eEF2 kinase, and these effects are blocked by rapamycin, which inhibits the mammalian target of rapamycin, mTOR. However, the signalling mechanisms underlying these effects are unknown. Regulation of eEF2 phosphorylation and eEF2k activity is lost in cells in which phosphoinositide-dependent kinase 1 (PDK1) ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID