An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers Intestinal Inflammation via Expansion of Gamma-Delta T Cells.

Suhail A, Rizvi ZA, Mujagond P, Ali SA, Gaur P, Singh M, Ahuja V, Awasthi A, Srikanth CV

Inflammatory bowel disease (IBD) is a complex autoimmune disorder recently shown to be associated with SUMOylation, a post-translational modification mechanism. Here, we have identified a link between epithelial deSUMOylases and inflammation in IBD. DeSUMOylase SENP7 was seen to be upregulated specifically in intestinal epithelial cells in both human IBD and a mouse model. In steady state, but not IBD, SENP7 ... [more]

Cell Rep Dec. 10, 2019; 29(11);3522-3538.e7 [Pubmed: 31825833]

Throughput

High Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CBX5 SENP7	Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.	Ostapcuk V (2018)	High	-	BioGRID	-

Curated By

BioGRID

Interaction Summary

SENP7

Gene Ontology Cellular Component

CBX5

Gene Ontology Biological Process

Gene Ontology Molecular Function

chromatin binding [IDA]histone deacetylase binding [IPI]methylated histone binding [ISO]protein binding [IPI]protein binding, bridging [IPI]protein homodimerization activity [IPI]repressing transcription factor binding [IPI]