BAIT
SENP7
2410152H17Rik, 2810413I22Rik, 2900036C23Rik, 6030449K19Rik, AI790676, mKIAA1707
SUMO1/sentrin specific peptidase 7
GO Process (0)
GO Function (0)
GO Component (2)
Gene Ontology Cellular Component
Mus musculus
PREY
PLK1
Plk, STPK13
polo-like kinase 1
GO Process (27)
GO Function (6)
GO Component (12)
Gene Ontology Biological Process
- G2 DNA damage checkpoint [ISO]
- G2/M transition of mitotic cell cycle [ISO]
- activation of mitotic anaphase-promoting complex activity [ISO]
- centrosome organization [ISO]
- cytokinesis [ISO]
- establishment of protein localization [ISO]
- microtubule bundle formation [ISO]
- mitotic cytokinesis [ISO]
- mitotic nuclear division [ISO]
- mitotic sister chromatid segregation [ISO]
- mitotic spindle assembly checkpoint [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- peptidyl-serine phosphorylation [ISO]
- polar body extrusion after meiotic divisions [ISO]
- positive regulation of peptidyl-threonine phosphorylation [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of proteolysis [ISO]
- positive regulation of ubiquitin-protein transferase activity [ISO]
- protein destabilization [ISO]
- protein localization to chromatin [ISO]
- protein phosphorylation [IDA, ISO]
- protein ubiquitination [ISO]
- regulation of mitotic cell cycle [ISO]
- regulation of mitotic metaphase/anaphase transition [ISO]
- regulation of protein binding [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers Intestinal Inflammation via Expansion of Gamma-Delta T Cells.
Inflammatory bowel disease (IBD) is a complex autoimmune disorder recently shown to be associated with SUMOylation, a post-translational modification mechanism. Here, we have identified a link between epithelial deSUMOylases and inflammation in IBD. DeSUMOylase SENP7 was seen to be upregulated specifically in intestinal epithelial cells in both human IBD and a mouse model. In steady state, but not IBD, SENP7 ... [more]
Cell Rep Dec. 10, 2019; 29(11);3522-3538.e7 [Pubmed: 31825833]
Throughput
- High Throughput
Curated By
- BioGRID