BAIT
SENP7
2410152H17Rik, 2810413I22Rik, 2900036C23Rik, 6030449K19Rik, AI790676, mKIAA1707
SUMO1/sentrin specific peptidase 7
GO Process (0)
GO Function (0)
GO Component (2)
Gene Ontology Cellular Component
Mus musculus
PREY
BIRC2
AW146227, Api1, Api2, Birc3, HIAP1, HIAP2, IAP1, IAP2, MIAP1, MIAP2, MIHB, MIHC, RNF48, cIAP1, cIAP2, mcIAP1
baculoviral IAP repeat-containing 2
GO Process (21)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- cytokinesis [IBA]
- inhibition of cysteine-type endopeptidase activity involved in apoptotic process [IBA]
- necroptotic process [IMP]
- negative regulation of apoptotic process [IBA, ISO]
- negative regulation of necroptotic process [IGI]
- negative regulation of ripoptosome assembly involved in necroptotic process [IGI]
- placenta development [IMP]
- positive regulation of protein K48-linked ubiquitination [ISO]
- positive regulation of protein K63-linked ubiquitination [ISO]
- positive regulation of protein monoubiquitination [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein heterooligomerization [ISO]
- protein polyubiquitination [ISO]
- protein ubiquitination [IBA]
- regulation of apoptotic process [ISO]
- regulation of cell cycle [ISO]
- regulation of necroptotic process [ISO]
- regulation of nucleic acid-templated transcription [ISO]
- regulation of reactive oxygen species metabolic process [IMP]
- regulation of toll-like receptor signaling pathway [IBA]
- response to hypoxia [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers Intestinal Inflammation via Expansion of Gamma-Delta T Cells.
Inflammatory bowel disease (IBD) is a complex autoimmune disorder recently shown to be associated with SUMOylation, a post-translational modification mechanism. Here, we have identified a link between epithelial deSUMOylases and inflammation in IBD. DeSUMOylase SENP7 was seen to be upregulated specifically in intestinal epithelial cells in both human IBD and a mouse model. In steady state, but not IBD, SENP7 ... [more]
Cell Rep Dec. 10, 2019; 29(11);3522-3538.e7 [Pubmed: 31825833]
Throughput
- High Throughput
Curated By
- BioGRID