BAIT
SENP7
2410152H17Rik, 2810413I22Rik, 2900036C23Rik, 6030449K19Rik, AI790676, mKIAA1707
SUMO1/sentrin specific peptidase 7
GO Process (0)
GO Function (0)
GO Component (2)
Gene Ontology Cellular Component
Mus musculus
PREY
CARD9
Gm782, RP23-306D20.2
caspase recruitment domain family, member 9
GO Process (17)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [ISO]
- defense response to Gram-positive bacterium [IMP]
- defense response to virus [IMP]
- positive regulation of JNK cascade [IMP, ISA]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of innate immune response [IMP]
- positive regulation of interleukin-6 production [IMP]
- positive regulation of stress-activated MAPK cascade [IMP, ISA]
- positive regulation of tumor necrosis factor production [IMP]
- regulation of interleukin-2 biosynthetic process [IMP]
- regulation of interleukin-6 biosynthetic process [IMP]
- regulation of tumor necrosis factor biosynthetic process [IMP]
- response to drug [IMP]
- response to exogenous dsRNA [IMP]
- response to fungus [IMP]
- response to muramyl dipeptide [IMP]
- response to peptidoglycan [IMP]
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers Intestinal Inflammation via Expansion of Gamma-Delta T Cells.
Inflammatory bowel disease (IBD) is a complex autoimmune disorder recently shown to be associated with SUMOylation, a post-translational modification mechanism. Here, we have identified a link between epithelial deSUMOylases and inflammation in IBD. DeSUMOylase SENP7 was seen to be upregulated specifically in intestinal epithelial cells in both human IBD and a mouse model. In steady state, but not IBD, SENP7 ... [more]
Cell Rep Dec. 10, 2019; 29(11);3522-3538.e7 [Pubmed: 31825833]
Throughput
- High Throughput
Curated By
- BioGRID