BAIT
SENP7
2410152H17Rik, 2810413I22Rik, 2900036C23Rik, 6030449K19Rik, AI790676, mKIAA1707
SUMO1/sentrin specific peptidase 7
GO Process (0)
GO Function (0)
GO Component (2)
Gene Ontology Cellular Component
Mus musculus
PREY
S100A9
60B8Ag, AW546964, BEE22, Cagb, GAGB, L1Ag, MRP14, p14
S100 calcium binding protein A9 (calgranulin B)
GO Process (11)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [IMP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- autophagy [ISO]
- leukocyte chemotaxis [IMP]
- leukocyte migration involved in inflammatory response [ISO]
- neutrophil aggregation [ISO]
- neutrophil chemotaxis [ISO]
- positive regulation of inflammatory response [ISO]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- positive regulation of peptide secretion [IDA, IMP]
- regulation of integrin biosynthetic process [IMP]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers Intestinal Inflammation via Expansion of Gamma-Delta T Cells.
Inflammatory bowel disease (IBD) is a complex autoimmune disorder recently shown to be associated with SUMOylation, a post-translational modification mechanism. Here, we have identified a link between epithelial deSUMOylases and inflammation in IBD. DeSUMOylase SENP7 was seen to be upregulated specifically in intestinal epithelial cells in both human IBD and a mouse model. In steady state, but not IBD, SENP7 ... [more]
Cell Rep Dec. 10, 2019; 29(11);3522-3538.e7 [Pubmed: 31825833]
Throughput
- High Throughput
Curated By
- BioGRID