BAIT
RPS6KB1
ribosomal protein S6 kinase, polypeptide 1
GO Process (43)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO]
- TOR signaling [ISO]
- aging [IEP]
- cell migration [IEP]
- cellular response to growth factor stimulus [ISO, ISS]
- cellular response to hormone stimulus [IEP]
- germ cell development [ISO]
- long-term memory [IEP]
- negative regulation of apoptotic process [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- negative regulation of insulin receptor signaling pathway [IMP, ISO]
- positive regulation of mitotic cell cycle [ISO]
- positive regulation of skeletal muscle tissue growth [IMP]
- positive regulation of smooth muscle cell migration [IMP]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of translation [ISO]
- positive regulation of translational initiation [ISO]
- protein kinase B signaling [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of glucose import [IMP]
- response to amino acid [IEP]
- response to drug [IEP]
- response to electrical stimulus involved in regulation of muscle adaptation [IEP]
- response to ethanol [IEP]
- response to glucagon [IEP]
- response to glucocorticoid [IEP]
- response to glucose [IEP]
- response to heat [IEP]
- response to insulin [IEP, IMP]
- response to leucine [IEP]
- response to lipopolysaccharide [IEP]
- response to mechanical stimulus [IEP]
- response to nutrient [IEP]
- response to organic cyclic compound [IEP]
- response to organic substance [IEP]
- response to organonitrogen compound [IEP]
- response to peptide hormone [IEP]
- response to testosterone [IEP]
- response to toxic substance [IEP]
- response to tumor necrosis factor [IMP]
- response to wounding [IEP]
- skeletal muscle atrophy [IEP]
- skeletal muscle contraction [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
CSNK2B
CK2B, CK2N, CSK2B, G5A, DADB-127H9.2
casein kinase 2, beta polypeptide
GO Process (13)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- adiponectin-activated signaling pathway [IDA]
- axon guidance [TAS]
- cellular protein complex assembly [NAS]
- endothelial tube morphogenesis [IMP]
- mitotic cell cycle [TAS]
- negative regulation of blood vessel endothelial cell migration [IDA]
- negative regulation of cell proliferation [TAS]
- positive regulation of activin receptor signaling pathway [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- protein phosphorylation [TAS]
- regulation of DNA binding [NAS]
- regulation of protein kinase activity [NAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Nuclear export of S6K1 II is regulated by protein kinase CK2 phosphorylation at Ser-17.
Ribosomal S6 kinases (S6Ks) are principal players in the regulation of cell growth and energy metabolism. Signaling via phosphatidylinositol 3-kinase and mammalian target of rapamycin pathways mediates the activation of S6K in response to various mitogenic stimuli. The family of S6Ks consists of two forms, S6K1 and -2, that have cytoplasmic and nuclear splicing variants, S6K1 II and S6K1 I, ... [more]
J. Biol. Chem. Oct. 20, 2006; 281(42);31188-201 [Pubmed: 16895915]
Throughput
- Low Throughput
Curated By
- BioGRID