MTOR
Gene Ontology Biological Process
- TOR signaling [ISO]
- cell growth [ISO]
- cell projection organization [IGI, ISO]
- cellular response to hypoxia [ISO, ISS]
- cellular response to nutrient levels [ISO, ISS]
- double-strand break repair via homologous recombination [IBA]
- germ cell development [ISO]
- negative regulation of NFAT protein import into nucleus [ISO]
- negative regulation of autophagy [ISO, ISS]
- negative regulation of cell size [IMP, ISO]
- negative regulation of macroautophagy [ISO]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- phosphorylation [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of lamellipodium assembly [ISO]
- positive regulation of lipid biosynthetic process [ISO, ISS]
- positive regulation of myotube differentiation [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of stress fiber assembly [ISO]
- positive regulation of transcription from RNA polymerase III promoter [ISO]
- positive regulation of translation [IMP, ISO]
- protein autophosphorylation [IMP, ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of Rac GTPase activity [ISO]
- regulation of actin cytoskeleton organization [ISO]
- regulation of carbohydrate metabolic process [IDA, IMP]
- regulation of carbohydrate utilization [IDA, IMP]
- regulation of fatty acid beta-oxidation [IDA, IMP]
- regulation of glycogen biosynthetic process [IDA, IMP]
- regulation of myelination [ISO]
- regulation of protein kinase activity [ISO]
- regulation of response to food [IDA, IMP]
- response to amino acid [ISO]
- response to insulin [ISO]
- ruffle organization [ISO]
Gene Ontology Molecular Function- RNA polymerase III type 1 promoter DNA binding [ISO]
- RNA polymerase III type 2 promoter DNA binding [ISO]
- RNA polymerase III type 3 promoter DNA binding [ISO]
- TFIIIC-class transcription factor binding [ISO]
- kinase activity [ISO]
- phosphoprotein binding [ISO]
- protein binding [IPI]
- protein dimerization activity [IBA]
- protein domain specific binding [IPI]
- protein serine/threonine kinase activity [IDA, IMP, ISO]
- ribosome binding [ISO]
- RNA polymerase III type 1 promoter DNA binding [ISO]
- RNA polymerase III type 2 promoter DNA binding [ISO]
- RNA polymerase III type 3 promoter DNA binding [ISO]
- TFIIIC-class transcription factor binding [ISO]
- kinase activity [ISO]
- phosphoprotein binding [ISO]
- protein binding [IPI]
- protein dimerization activity [IBA]
- protein domain specific binding [IPI]
- protein serine/threonine kinase activity [IDA, IMP, ISO]
- ribosome binding [ISO]
EIF4EBP1
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- TOR signaling [IDA]
- cellular protein metabolic process [TAS]
- gene expression [TAS]
- insulin receptor signaling pathway [TAS]
- negative regulation of translational initiation [IDA]
- positive regulation of mitotic cell cycle [IMP]
- translation [TAS]
- translational initiation [TAS]
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism.
The multisubunit eukaryotic translation initiation factor (eIF) 4F recruits 40S ribosomal subunits to the 5' end of mRNA. The eIF4F subunit eIF4E interacts directly with the mRNA 5' cap structure. Assembly of the eIF4F complex is inhibited by a family of repressor polypeptides, the eIF4E-binding proteins (4E-BPs). Binding of the 4E-BPs to eIF4E is regulated by phosphorylation: Hypophosphorylated 4E-BP isoforms ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MTOR EIF4EBP1 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 1036488 |
Curated By
- BioGRID