BAIT
DUX4
DUX4L
double homeobox 4
GO Process (4)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NME1
AL024257, NDPK-A, NM23-M1, NM23A, RP23-378I13.1
NME/NM23 nucleoside diphosphate kinase 1
GO Process (14)
GO Function (14)
GO Component (10)
Gene Ontology Biological Process
- DNA catabolic process [ISO]
- lactation [IMP]
- mammary gland development [IMP]
- negative regulation of gene expression [ISO]
- negative regulation of myeloid leukocyte differentiation [ISO]
- nucleic acid phosphodiester bond hydrolysis [ISO]
- nucleoside diphosphate phosphorylation [IBA, ISO]
- nucleoside triphosphate biosynthetic process [IBA]
- positive regulation of DNA binding [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of neuron projection development [ISO]
- purine nucleotide metabolic process [IBA]
- pyrimidine nucleotide metabolic process [IBA]
- regulation of apoptotic process [IBA]
Gene Ontology Molecular Function- ATP binding [ISO]
- GTP binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- deoxyribonuclease activity [ISO]
- enzyme binding [ISO]
- gamma-tubulin binding [ISO]
- identical protein binding [ISO]
- intermediate filament binding [ISO]
- magnesium ion binding [ISO]
- nucleoside diphosphate kinase activity [IBA, ISO]
- poly(A) RNA binding [ISO]
- protein kinase binding [ISO]
- ribosomal small subunit binding [ISO]
- single-stranded DNA binding [ISO]
- ATP binding [ISO]
- GTP binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- deoxyribonuclease activity [ISO]
- enzyme binding [ISO]
- gamma-tubulin binding [ISO]
- identical protein binding [ISO]
- intermediate filament binding [ISO]
- magnesium ion binding [ISO]
- nucleoside diphosphate kinase activity [IBA, ISO]
- poly(A) RNA binding [ISO]
- protein kinase binding [ISO]
- ribosomal small subunit binding [ISO]
- single-stranded DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation.
Hundreds of double homeobox (DUX) genes map within 3.3-kb repeated elements dispersed in the human genome and encode DNA-binding proteins. Among these, we identified DUX4, a potent transcription factor that causes facioscapulohumeral muscular dystrophy (FSHD). In the present study, we performed yeast two-hybrid screens and protein co-purifications with HaloTag-DUX fusions or GST-DUX4 pull-down to identify protein partners of DUX4, DUX4c ... [more]
Unknown Jan. 28, 2016; 11(1);e0146893 [Pubmed: 26816005]
Throughput
- High Throughput
Additional Notes
- hits identified in 2H (two-hybrid) screen using human DUX4 as the bait against a mouse cDNA library
Curated By
- BioGRID