BAIT
PDK1
pyruvate dehydrogenase kinase, isozyme 1
GO Process (9)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- cell proliferation [IMP]
- cellular metabolic process [TAS]
- hypoxia-inducible factor-1alpha signaling pathway [IMP]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IMP]
- protein phosphorylation [IDA, IMP]
- pyruvate metabolic process [TAS]
- regulation of acetyl-CoA biosynthetic process from pyruvate [TAS]
- regulation of glucose metabolic process [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RPS6KB1
PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70 S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha
ribosomal protein S6 kinase, 70kDa, polypeptide 1
GO Process (12)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- TOR signaling [IDA]
- cellular response to growth factor stimulus [IDA]
- insulin receptor signaling pathway [TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of insulin receptor signaling pathway [IMP]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of mitotic cell cycle [IMP]
- positive regulation of translation [IMP]
- positive regulation of translational initiation [IMP]
- protein phosphorylation [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha.
BACKGROUND: A novel ribosomal S6 kinase, termed p70 S6 kinase beta (p70beta), has a highly homologous amino acid sequence to that of p70/p85 S6 kinase (p70alpha). This includes the critical phosphorylation sites, Thr252, Ser394 and Thr412 in p70alpha1, which correspond to Thr241, Ser383 and Thr401 in p70beta1, respectively. However, the regulatory mechanism for p70beta remains to be elucidated. RESULTS: We ... [more]
Genes Cells Nov. 01, 2001; 6(11);1003-15 [Pubmed: 11733037]
Throughput
- Low Throughput
Curated By
- BioGRID