BAIT
MTOR
Frap1, RAFT1
mechanistic target of rapamycin (serine/threonine kinase)
GO Process (40)
GO Function (11)
GO Component (13)
Gene Ontology Biological Process
- TOR signaling [ISO]
- cell growth [ISO]
- cell projection organization [IGI, ISO]
- cellular response to hypoxia [ISO, ISS]
- cellular response to nutrient levels [ISO, ISS]
- double-strand break repair via homologous recombination [IBA]
- germ cell development [ISO]
- negative regulation of NFAT protein import into nucleus [ISO]
- negative regulation of autophagy [ISO, ISS]
- negative regulation of cell size [IMP, ISO]
- negative regulation of macroautophagy [ISO]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- phosphorylation [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of lamellipodium assembly [ISO]
- positive regulation of lipid biosynthetic process [ISO, ISS]
- positive regulation of myotube differentiation [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of stress fiber assembly [ISO]
- positive regulation of transcription from RNA polymerase III promoter [ISO]
- positive regulation of translation [IMP, ISO]
- protein autophosphorylation [IMP, ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of Rac GTPase activity [ISO]
- regulation of actin cytoskeleton organization [ISO]
- regulation of carbohydrate metabolic process [IDA, IMP]
- regulation of carbohydrate utilization [IDA, IMP]
- regulation of fatty acid beta-oxidation [IDA, IMP]
- regulation of glycogen biosynthetic process [IDA, IMP]
- regulation of myelination [ISO]
- regulation of protein kinase activity [ISO]
- regulation of response to food [IDA, IMP]
- response to amino acid [ISO]
- response to insulin [ISO]
- ruffle organization [ISO]
Gene Ontology Molecular Function- RNA polymerase III type 1 promoter DNA binding [ISO]
- RNA polymerase III type 2 promoter DNA binding [ISO]
- RNA polymerase III type 3 promoter DNA binding [ISO]
- TFIIIC-class transcription factor binding [ISO]
- kinase activity [ISO]
- phosphoprotein binding [ISO]
- protein binding [IPI]
- protein dimerization activity [IBA]
- protein domain specific binding [IPI]
- protein serine/threonine kinase activity [IDA, IMP, ISO]
- ribosome binding [ISO]
- RNA polymerase III type 1 promoter DNA binding [ISO]
- RNA polymerase III type 2 promoter DNA binding [ISO]
- RNA polymerase III type 3 promoter DNA binding [ISO]
- TFIIIC-class transcription factor binding [ISO]
- kinase activity [ISO]
- phosphoprotein binding [ISO]
- protein binding [IPI]
- protein dimerization activity [IBA]
- protein domain specific binding [IPI]
- protein serine/threonine kinase activity [IDA, IMP, ISO]
- ribosome binding [ISO]
Rattus norvegicus
PREY
GPHN
GEPH, GPH, GPHRYN, HKPX1, MOCODC
gephyrin
GO Process (4)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling.
RAFT1 (rapamycin and FKBP12 target 1; also called FRAP or mTOR) is a member of the ATM (ataxia telangiectasia mutated)-related family of proteins and functions as the in vivo mediator of the effects of the immunosuppressant rapamycin and as an important regulator of messenger RNA translation. In mammalian cells RAFT1 interacted with gephyrin, a widely expressed protein necessary for the ... [more]
Science May. 14, 1999; 284(5417);1161-4 [Pubmed: 10325225]
Throughput
- Low Throughput
Curated By
- BioGRID