BAIT
TSC1
RP23-362N19.3
tuberous sclerosis 1
GO Process (33)
GO Function (5)
GO Component (12)
Gene Ontology Biological Process
- activation of Rho GTPase activity [ISO]
- cardiac muscle cell differentiation [IMP]
- cell projection organization [IMP]
- cell-matrix adhesion [ISO]
- cerebral cortex development [IMP]
- embryo development [IMP]
- glucose import [IMP]
- hippocampus development [IMP]
- kidney development [IMP]
- myelination [IMP]
- negative regulation of TOR signaling [IBA, ISO]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of cell size [IGI, IMP]
- negative regulation of insulin receptor signaling pathway [IBA]
- negative regulation of translation [ISO]
- nervous system development [IMP]
- neural tube closure [IMP]
- positive regulation of focal adhesion assembly [ISO]
- potassium ion transport [IGI, IMP]
- protein heterooligomerization [ISO]
- protein stabilization [ISO]
- rRNA export from nucleus [ISO]
- regulation of Ras GTPase activity [IBA]
- regulation of actin cytoskeleton organization [IBA, ISO]
- regulation of cell cycle [IBA]
- regulation of cell-matrix adhesion [ISO]
- regulation of focal adhesion assembly [ISO]
- regulation of phosphoprotein phosphatase activity [ISO]
- regulation of protein kinase activity [IGI]
- regulation of stress fiber assembly [ISO]
- regulation of translation [ISO]
- response to insulin [ISO]
- synapse organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MSN
C78546, RP23-98K7.1
moesin
GO Process (3)
GO Function (5)
GO Component (21)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [ISO]
- apical part of cell [IDA, ISO]
- apical plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- blood microparticle [ISO]
- cell periphery [ISO]
- cell surface [ISO]
- cell tip [ISO]
- cytoplasm [ISO]
- cytoplasmic side of plasma membrane [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- filopodium [ISO]
- filopodium membrane [ISO]
- focal adhesion [ISO]
- microvillus [ISO]
- myelin sheath [IDA]
- plasma membrane [ISO]
- secretory granule membrane [ISO]
- uropod [IDA]
- vesicle [ISO]
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho.
Loss of the tumour-suppressor gene TSC1 is responsible for hamartoma development in tuberous sclerosis complex (TSC), which renders several organs susceptible to benign tumours. Hamartin, the protein encoded by TSC1, contains a coiled-coil domain and is expressed in most adult tissues, although its function is unknown. Here we show that hamartin interacts with the ezrin-radixin-moesin (ERM) family of actin-binding proteins. ... [more]
Nat. Cell Biol. May. 01, 2000; 2(5);281-7 [Pubmed: 10806479]
Throughput
- Low Throughput
Curated By
- BioGRID