BAIT
TSC1
tuberous sclerosis 1
GO Process (32)
GO Function (4)
GO Component (12)
Gene Ontology Biological Process
- activation of Rho GTPase activity [ISO]
- cardiac muscle cell differentiation [ISO]
- cell projection organization [ISO]
- cell-matrix adhesion [ISO]
- cerebral cortex development [ISO]
- glucose import [ISO]
- hippocampus development [ISO]
- kidney development [ISO]
- myelination [ISO]
- negative regulation of TOR signaling [IBA, ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of cell size [ISO]
- negative regulation of insulin receptor signaling pathway [IBA]
- negative regulation of translation [ISO]
- nervous system development [ISO]
- neural tube closure [ISO]
- positive regulation of focal adhesion assembly [ISO]
- potassium ion transport [ISO]
- protein heterooligomerization [IDA]
- protein stabilization [ISO]
- rRNA export from nucleus [ISO]
- regulation of Ras GTPase activity [IBA]
- regulation of actin cytoskeleton organization [IMP]
- regulation of cell cycle [IBA]
- regulation of cell-matrix adhesion [ISO]
- regulation of focal adhesion assembly [IMP]
- regulation of phosphoprotein phosphatase activity [ISO]
- regulation of protein kinase activity [ISO]
- regulation of stress fiber assembly [IMP, ISO]
- regulation of translation [ISO]
- response to insulin [ISO]
- synapse organization [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
REN
RATRENAA, RENAA, Ren1
renin
GO Process (19)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- angiotensin maturation [IDA, ISO]
- beta-amyloid metabolic process [IEP]
- cell maturation [ISO]
- cellular response to drug [IEP]
- drinking behavior [ISO]
- establishment of blood-nerve barrier [ISO]
- hormone-mediated signaling pathway [ISO]
- kidney development [ISO]
- proteolysis [ISO]
- regulation of MAPK cascade [ISO]
- regulation of blood pressure [IMP, TAS]
- regulation of blood volume by renin-angiotensin [ISO]
- renin-angiotensin regulation of aldosterone production [ISO]
- response to cAMP [IDA]
- response to cGMP [IDA]
- response to drug [IDA]
- response to immobilization stress [IEP]
- response to lipopolysaccharide [IEP]
- response to organic substance [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Similarities and differences in the subcellular localization of hamartin and tuberin in the kidney.
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by hamartomas in multiple organs, notably the brain and kidneys. The disease is caused by mutations in TSC1 or TSC2 genes, coding hamartin and tuberin, respectively. Immunofluorescence analysis of tuberin and hamartin performed here demonstrates that both proteins are specifically expressed in the distal urinary tubule, comprising the distal tubules, ... [more]
Am. J. Physiol. Renal Physiol. May. 01, 2000; 278(5);F737-46 [Pubmed: 10807585]
Throughput
- Low Throughput
Curated By
- BioGRID