BAIT
NEFL
NF-L, Nfl
neurofilament, light polypeptide
GO Process (21)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- anterograde axon cargo transport [ISO]
- axon transport of mitochondrion [ISO]
- intermediate filament bundle assembly [ISO]
- intermediate filament organization [ISO]
- locomotion [ISO]
- microtubule cytoskeleton organization [ISO]
- negative regulation of neuron apoptotic process [ISO]
- neurofilament bundle assembly [ISO]
- neurofilament cytoskeleton organization [ISO]
- neuromuscular process controlling balance [ISO]
- neuron projection morphogenesis [ISO]
- peripheral nervous system axon regeneration [ISO]
- positive regulation of axonogenesis [ISO]
- protein polymerization [IDA]
- regulation of axon diameter [ISO]
- response to corticosterone [IEP]
- response to organic substance [IEP]
- response to organonitrogen compound [IEP]
- response to peptide hormone [IEP]
- response to toxic substance [IEP]
- retrograde axon cargo transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
TSC2
Rc
tuberous sclerosis 2
GO Process (34)
GO Function (7)
GO Component (18)
Gene Ontology Biological Process
- acute-phase response [IMP]
- cell projection organization [IGI, IMP]
- cellular response to insulin stimulus [ISO]
- establishment of protein localization [IMP]
- glucose import [ISO]
- heart development [ISO]
- insulin-like growth factor receptor signaling pathway [ISO]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of TOR signaling [IDA, ISO]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of cell size [IMP]
- negative regulation of epithelial cell proliferation [IDA]
- negative regulation of insulin receptor signaling pathway [IBA]
- negative regulation of phosphatidylinositol 3-kinase signaling [ISO]
- negative regulation of protein kinase B signaling [IBA, ISO]
- negative regulation of protein kinase activity [ISO]
- neural tube closure [ISO]
- phosphatidylinositol 3-kinase signaling [ISO]
- positive chemotaxis [ISO]
- positive regulation of Rab GTPase activity [TAS]
- positive regulation of Ras GTPase activity [IBA]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein heterooligomerization [IDA, IMP]
- protein homooligomerization [IDA, IMP]
- protein import into nucleus [ISO]
- protein kinase B signaling [ISO]
- protein localization [ISO]
- protein transport into plasma membrane raft [ISO]
- regulation of cell cycle [IMP]
- regulation of endocytosis [ISO]
- regulation of insulin receptor signaling pathway [ISO]
- response to hypoxia [ISO]
- signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- TSC1-TSC2 complex [IBA, ISO]
- caveola [IDA]
- cell [ISO]
- cytoplasm [ISO]
- cytoskeleton [IDA]
- cytosol [IDA, ISO]
- dendrite [IDA]
- growth cone [IDA]
- intracellular [ISO]
- intracellular membrane-bounded organelle [IDA]
- membrane [ISO]
- membrane raft [IDA]
- neuron projection [IDA]
- neuronal cell body [IDA]
- nucleus [ISO]
- perinuclear region of cytoplasm [IDA, ISO]
- protein complex [IDA]
Rattus norvegicus
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton.
Tuberous sclerosis complex, an autosomal dominant disease caused by mutations in either TSC1 or TSC2, is characterized by the development of hamartomas in a variety of organs. The proteins encoded by TSC1 and TSC2, hamartin and tuberin, respectively, associate with each other forming a tight complex. Here we show that hamartin binds the neurofilament light chain and it is possible ... [more]
J. Biol. Chem. Nov. 15, 2002; 277(46);44180-6 [Pubmed: 12226091]
Throughput
- Low Throughput
Curated By
- BioGRID