ZFP36
Gene Ontology Biological Process
- 3'-UTR-mediated mRNA stabilization [ISO]
- RNA destabilization [IMP]
- intracellular signal transduction [IDA]
- mRNA catabolic process [ISO]
- negative regulation of inflammatory response [IMP]
- negative regulation of myeloid cell differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- negative regulation of translation involved in gene silencing by miRNA [IDA]
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [IDA, ISO]
- nuclear-transcribed mRNA poly(A) tail shortening [IDA]
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [IDA]
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [IDA, ISO]
- regulation of mRNA stability [IDA]
- regulation of transcription from RNA polymerase II promoter [IGI]
- regulation of tumor necrosis factor production [ISO]
- response to starvation [ISO]
Gene Ontology Molecular Function
YWHAB
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Tristetraprolin regulates Cyclin D1 and c-Myc mRNA stability in response to rapamycin in an Akt-dependent manner via p38 MAPK signaling.
The differential expression of the critical cell cycle control proteins cyclin D1 and c-myc has been shown to result in Akt-dependent hypersensitivity of tumor cells to mTOR inhibitors. We have previously demonstrated that the differential utilization of internal ribosome entry sites within the mRNAs of these transcripts allows maintenance of protein synthesis in the face of rapamycin (rapa) exposure in ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID