BAIT
NEFL
NF-L, Nfl
neurofilament, light polypeptide
GO Process (21)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- anterograde axon cargo transport [ISO]
- axon transport of mitochondrion [ISO]
- intermediate filament bundle assembly [ISO]
- intermediate filament organization [ISO]
- locomotion [ISO]
- microtubule cytoskeleton organization [ISO]
- negative regulation of neuron apoptotic process [ISO]
- neurofilament bundle assembly [ISO]
- neurofilament cytoskeleton organization [ISO]
- neuromuscular process controlling balance [ISO]
- neuron projection morphogenesis [ISO]
- peripheral nervous system axon regeneration [ISO]
- positive regulation of axonogenesis [ISO]
- protein polymerization [IDA]
- regulation of axon diameter [ISO]
- response to corticosterone [IEP]
- response to organic substance [IEP]
- response to organonitrogen compound [IEP]
- response to peptide hormone [IEP]
- response to toxic substance [IEP]
- retrograde axon cargo transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
TSC1
tuberous sclerosis 1
GO Process (32)
GO Function (4)
GO Component (12)
Gene Ontology Biological Process
- activation of Rho GTPase activity [ISO]
- cardiac muscle cell differentiation [ISO]
- cell projection organization [ISO]
- cell-matrix adhesion [ISO]
- cerebral cortex development [ISO]
- glucose import [ISO]
- hippocampus development [ISO]
- kidney development [ISO]
- myelination [ISO]
- negative regulation of TOR signaling [IBA, ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of cell size [ISO]
- negative regulation of insulin receptor signaling pathway [IBA]
- negative regulation of translation [ISO]
- nervous system development [ISO]
- neural tube closure [ISO]
- positive regulation of focal adhesion assembly [ISO]
- potassium ion transport [ISO]
- protein heterooligomerization [IDA]
- protein stabilization [ISO]
- rRNA export from nucleus [ISO]
- regulation of Ras GTPase activity [IBA]
- regulation of actin cytoskeleton organization [IMP]
- regulation of cell cycle [IBA]
- regulation of cell-matrix adhesion [ISO]
- regulation of focal adhesion assembly [IMP]
- regulation of phosphoprotein phosphatase activity [ISO]
- regulation of protein kinase activity [ISO]
- regulation of stress fiber assembly [IMP, ISO]
- regulation of translation [ISO]
- response to insulin [ISO]
- synapse organization [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton.
Tuberous sclerosis complex, an autosomal dominant disease caused by mutations in either TSC1 or TSC2, is characterized by the development of hamartomas in a variety of organs. The proteins encoded by TSC1 and TSC2, hamartin and tuberin, respectively, associate with each other forming a tight complex. Here we show that hamartin binds the neurofilament light chain and it is possible ... [more]
J. Biol. Chem. Nov. 15, 2002; 277(46);44180-6 [Pubmed: 12226091]
Throughput
- Low Throughput
Curated By
- BioGRID